| Trazodone |
Priapism |
| Aspirin |
Gastrointestinal (GI) bleeding, hypersensitivity |
| Bleomycin |
Pulmonary fibrosis |
| Cyclophosphamide |
Hemorrhagic cystitis |
| Bupropion |
Seizures |
| Isoniazid |
Vitamin B6 deficiency, lupus-like syndrome, liver toxicity |
| Cyclosporine |
Renal toxicity |
| Penicillins |
Anaphylaxis; rash with Epstein-Barr virus (EBV) |
| Angiotensin-converting enzyme (ACE) inhibitors |
Cough, angioedema |
| Demeclocycline |
Diabetes insipidus |
| Lithium |
Diabetes insipidus, thyroid dysfunction |
| Sulfa drugs |
Allergies, kernicterus in neonates |
| Halothane |
Liver necrosis |
| Local anesthetic |
Seizures |
| Phenytoin |
Folate deficiency, teratogen, hirsutism |
| Vincristine |
Peripheral neuropathy |
| Amiodarone |
Thyroid dysfunction, pulmonary toxicity |
| Valproic acid |
Neural tube defects in offspring |
| Isotretinoin |
Terrible teratogen |
| Thioridazine |
Retinal deposits, cardiac toxicity |
| Heparin |
Thrombocytopenia, thrombosis |
| Vancomycin |
Red man’s syndrome |
| Clofibrate |
Increased GI neoplasms |
| Tetracyclines |
Photosensitivity, teeth staining in children |
| Quinolones |
Teratogens (cartilage damage) |
| Quinine |
Cinchonism (tinnitus, vertigo), thrombocytopenia, QT prolongation |
| Morphine |
Sphincter of Oddi spasm |
| Clindamycin |
Pseudomembranous colitis (can be caused by any broad-spectrum antibiotic) |
| Chloramphenicol |
Aplastic anemia, gray-baby syndrome |
| Doxorubicin |
Cardiomyopathy |
| Busulfan |
Pulmonary fibrosis |
| Monoamine oxidase (MAO) inhibitors |
Tyramine crisis (after eating cheese or wine) |
| Hydralazine |
Lupus-like syndrome |
| Procainamide |
Lupus-like syndrome |
| Minoxidil |
Hirsutism |
| Aminoglycoside |
Hearing loss, renal toxicity |
| Acetaminophen |
Liver toxicity (in high doses) |
| Chlorpropamide |
Syndrome of inappropriate antidiuretic hormone (SIADH) |
| Oxytocin |
SIADH |
| Opiates |
SIADH |
| Didanosine (ddI) |
Pancreatitis, peripheral neuropathy |
| Halogen anesthesia |
Malignant hyperthermia |
| Succinylcholine |
Malignant hyperthermia |
| Zidovudine (AZT) |
Bone marrow suppression |
| Digitalis |
GI disorders, vision changes, arrhythmias |
| Acetazolamide |
Metabolic acidosis |
| Clozapine |
Agranulocytosis |
| Selective serotonin reuptake inhibitors (e.g., fluoxetine) |
Anxiety, agitation, insomnia, sexual dysfunction |
| Warfarin |
Necrosis, teratogen |
| Niacin |
Skin flushing, pruritus |
| HMG CoA reductase inhibitors (e.g., simvastatin) |
Liver and muscle toxicity |
| Ethambutol |
Optic neuritis |
| Metronidazole |
Disulfiram-like reaction with alcohol |
| Cisplatin |
Nephrotoxicity |
| Methyldopa |
Hemolytic anemia (Coombs test-positive) |
