Perampanel



Perampanel





(per am’ pah nel)

Fycompa

PREGNANCY CATEGORY C


Drug Classes

Antiepileptic

Glutamate receptor antagonist


Therapeutic Actions

Noncompetitive glutamate receptor antagonist; glutamate is a primary excitatory neurotransmitter; precise mechanism of antiepileptic effect is not understood.


Indications



  • Adjunct treatment of partial-onset seizures with or without secondary generalized seizures in patients 12 yr and older with epilepsy




Available Forms

Tablets—2, 4, 6, 8, 10, 12 mg


Dosages

Adults and children 12 yr and older

Starting dose, 2 mg/day PO at bedtime, 4 mg/day PO at bedtime if also taking other enzyme-inducing antiepileptics. May increase by maximum 2 mg/day at weekly intervals (every 2 wk in elderly patients) to maximum dose of 12 mg/day PO at bedtime.

Patients with mild to moderate hepatic impairment

Maximum daily dose is 6 mg/day PO at bedtime for mild impairment, 4 mg/day PO at bedtime for moderate impairment.

Patients with severe hepatic or renal impairment, patients on dialysis

Not recommended.

Jul 21, 2016 | Posted by in NURSING | Comments Off on Perampanel

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