Chapter 43 Oxygen therapy
INTRODUCTION
Adequate oxygenation is vital to prevent tissue damage. Prolonged hypoxia (a decreased availability of oxygen to the tissues) can result in cell death if allowed to persist, which ultimately leads to brain damage and multiorgan failure; 100% oxygen is therefore the first drug given in an emergency/resuscitation situation (Resuscitation Council UK 2005). Oxygen requirements can vary between individuals but are more significant in children as they have a lower pulmonary reserve and a higher metabolic rate than adults and can therefore decompensate more quickly if supplementary oxygen is not provided (Advanced Life Support Group 2005). Administering oxygen to children can be difficult, as they do not tolerate oxygen masks well, but nasal cannula and headboxes are often effective. Accuracy of the amount delivered can also be problematic as will be discussed later in this chapter. Oxygen can also be administered via an incubator but is not without problems (see Ch. 15).
LEARNING OUTCOMES
By the end of this section you should be able to:
FACTORS TO NOTE
Oxygen should be regarded as a drug and planned delivery of oxygen therapy should always be prescribed by a doctor (BMA 2006, Chandler 2001) As with any drug there can be adverse effects. Therefore, in any patient, oxygen should be delivered at the lowest concentration possible and for the shortest time possible (Chandler 2001, Wong et al 2002). Administration of oxygen to children is usually undertaken using one of three methods: via headbox, nasal cannula or oxygen mask. How much oxygen is delivered to the child is expressed as the fractional inspired oxygen concentration (FiO2) – literally, the percentage concentration of oxygen the child is breathing in.
Headbox or body/trunk box
This method of oxygen delivery is normally most suitable for infants and small children. The advantages of these types of device are that they give effective oxygen delivery, it is possible to reliably monitor the FiO2 and they are totally non-invasive. Disadvantages are that carbon dioxide re-breathing will occur at low oxygen flow rates, <4 L/min (Frey & Shann 2003), removal of the box quickly dilutes the oxygen delivered and a cold gas supply will quickly cool an infant. It is also desirable to humidify when prolonged oxygen therapy is required (Chandler 2001, Frey & Shann 2003, Pilkington 2004). Normally, inspired gas is warmed and humidified in the nasopharynx and reaches the upper trachea with a relative humidity of about 90% and a temperature of 32–36°C; it has reached a temperature of 37°C by the time it reaches the alveoli (Hazinski 1998). Mucociliary transport is impaired when relative humidity falls below 75% at 37°C (Pilkington 2004).
Nasal cannula
Nasal cannulae are available in different sizes, suitable for neonates through to adults. Advantages of nasal cannula are that they are reasonably well tolerated by children (particularly in comparison with an oxygen mask) and carbon dioxide re-breathing does not occur (Chandler 2001). Humidification is not necessary as the gas is entering via the nasal passages where it is warmed and moistened in the normal way (Frey & Shann 2003). Disadvantages are that nasal cannula are only suitable for use with a low flow of oxygen, i.e. maximum 2 L/min in neonates. Higher flows (>4 L/min) may be uncomfortable and dry the nasal mucosa (McGloin 2008). It is usually only possible to achieve an oxygen concentration of approximately 40–60% (EPLS 2006). In addition, a child who mouth breathes will dilute the FiO2 with air and oxygen concentrations are very dependent upon the infant or child’s breathing pattern.
Healthy children
Healthy children should have an arterial oxygen saturation level of 95–98% (Balfour-Lyn et al 2005). However, some children with chronic lung disease or who have cyanotic heart conditions may have an oxygen saturation level well below this, even when otherwise healthy. It is therefore essential for nurses to be aware of the child’s ‘norm’ and parents are a vital source of such information.
Neonates
Administration of continuous oxygen therapy to neonates must be monitored very carefully. High inspired oxygen concentrations have been clearly linked to the development of retinopathy of prematurity and prolonged exposure to high oxygen tensions may also cause pulmonary oxygen toxicity and permanent lung damage, e.g. bronchopulmonary dysplasia (BMA 2006, Kotecha & Allen 2002). However, very little is known about how much oxygen is safe to give and the target range of oxygen saturations in neonates is controversial (Tin & Gupta 2007). Recent studies have suggested that saturations of 92–94% in infants, particularly during the pre-term period, may be ideal (Askie et al 2003, Anon 2000).
Sick children
Recent studies have demonstrated that a child with chronic lung disease can and should have oxygen saturations maintained around 92–94% to provide a buffer zone against desaturation during sleeping and feeding. These targets also aim to reduce complications from pulmonary artery hypertension and promote growth (Kotecha & Allen 2002). However, in a small number of children with chronic lung disease, e.g. some children with cystic fibrosis, the dependence of respiratory drive on CO2 and bicarbonate concentration is lost. In these children, inflammatory changes in the lungs result in increased alveolar CO2 tension, which ultimately leads to a gross saturation of the chemoreceptors, making them dysfunctional. Administering high concentrations of oxygen to these children can cause carbon dioxide narcosis leading to unconsciousness (Chandler 2001). The BMA (2005) states that any patient with a chronic chest condition should not be administered more than 28% concentration of oxygen alongside repeated blood gas measurements.
GUIDELINES
Careful explanation to parents and child (if age and cognitive development allow) about the need for oxygen therapy will help to maximise cooperation. Careful explanation of all the equipment involved is important to minimise anxiety by reducing fear of the unknown. Parents can be taught how to perform oral care to help maintain a moist, clean mouth if oxygen therapy is causing drying of the mucosa (see Ch. 9).