Oxandrolone(ox an’ droh lone)
Oxandrin
PREGNANCY CATEGORY X
CONTROLLED SUBSTANCE C-III
Drug Classes
Anabolic steroid
Hormone
Therapeutic Actions
Testosterone analogue with androgenic and anabolic activity; promotes body tissue-building processes; reverses catabolic or tissue-depleting processes; increases Hgb and red cell mass.
Indications
Relief of bone pain accompanying osteoporosis
Adjunctive therapy to promote weight gain after weight loss following extensive surgery, chronic infections, trauma
Offset protein catabolism associated with prolonged use of corticosteroids
Orphan drug uses: Short stature associated with Turner syndrome, HIV wasting syndrome, and HIV-associated muscle weakness, Duchenne and Becker muscular dystrophies; constitutional delay of growth and puberty
Unlabeled use: Alcoholic hepatitis
Contraindications and Cautions
Contraindicated with known sensitivity to anabolic steroids; prostate, breast cancer; BPH; pituitary insufficiency; MI (contraindicated because of effects on cholesterol); nephrosis; liver disease; hypercalcemia; pregnancy, lactation.
Use cautiously with HF; cardiac, renal, or liver disease; epilepsy; migraines; diabetes.
Available Forms
Tablets—2.5 mg, 10 mg
Dosages
Adults
2.5 mg PO bid–qid; up to 20 mg has been used to achieve the desired effect; 2–4 wk needed to evaluate response.
Pediatric patients
Give a total daily dose of 0.1 mg/kg or less PO or 0.045 mg/lb or less PO; may be repeated intermittently.
Pharmacokinetics
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