CHAPTER 35 Nursing patients with sexually transmitted infections and HIV/AIDS
Introduction
Sexual infections have carried a significant social stigma throughout the ages; various acts of legislation, such as the Contagious Diseases Act 1864, confirmed abhorrence of these infections and sought to ‘blame’ individuals (usually women) for their spread (Cooper & Reid 2007). In the wake of an upsurge in sexual infections during the First World War, a different approach was adopted. In 1916 the Public Health (Venereal Diseases) Regulations heralded free and confidential SAI clinics for all (Clutterbuck 2008). As a result, gonorrhoea and syphilis became less common in the UK, compared with industrialised countries that still stigmatised these infections. The advent of penicillin was a major breakthrough in the treatment of SAIs. Treatment availability, along with the advent of the oral contraceptive pill, may have contributed to sexual freedom. Unfortunately the oral contraceptive pill led to a reduction in condom use and consequential rise in the incidence of SAIs experienced in the 1960s. Since this time, HIV has appeared on the scene. Faced once more with a potentially fatal and incurable SAI, society has looked for scapegoats, often incorrectly blaming those on the periphery of society.
The current trends in SAIs show that cases are still rising despite public health programmes and the ready, and often free, availability of barrier contraceptives such as condoms. Those most at risk of acquiring SAI include: young, single people; those who have multiple sexual partners; those who do not use barrier contraceptives; and those who live in metropolitan areas. Structural gender inequality, where women are forced into having unsafe sex as a byproduct of social, economic and gender disparity, is an additional factor (Gupta et al 2008). The number of all episodes of SAIs continues to increase in the UK.
Of all the SAIs, HIV has the most significant impact and it is on HIV that much of this chapter is focused. HIV is a global pandemic and has had a devastating effect on the developing world, in particular sub-Saharan Africa, which bears the greatest burden. The World Health Organization (WHO) estimated that in December 2007 over 33 million people worldwide were living with HIV, of whom two thirds live in sub-Saharan Africa, which also bears the brunt of new infections and death from acquired immune deficiency syndrome – AIDS (WHO 2008). In the UK, although there is a relatively low incidence when compared to many countries in the developing world, HIV continues to be a growing problem. In 2007 the Health Protection Agency (HPA) estimated that 77 400 people were living with HIV, of whom 7734 were newly diagnosed, and an increasing percentage (23%) were heterosexually acquired cases originating within the UK (HPA 2008b).
The role of the nurse
Partner notification
One of the most important aspects of nursing patients in a sexual health setting is the provision of partner notification (Trelle et al 2007). Health advisors attached to sexual health clinics organise partner notification. Only by encouraging patients to contact their partners to inform them of the chance of infection and then screening and treating those partners before further sexual activity, can the cycle of infection and re-infection be broken. In order to do this successfully, an accurate sexual history is of fundamental importance. Without a comprehensive and accurate history it can prove impossible to contact, screen and treat all affected parties. Although it is more effective if partner notification is performed by the patients themselves, health advisors may act in lieu of their patients and contact the patient’s sexual partners on their behalf.
The common sexually acquired/transmitted infections are discussed below, with some generalised treatment strategies; however, since this field of health care is evolving (particularly so with HIV), the drugs indicated are a rough guide rather than fixed treatment regimens, since in this dynamic area therapies often change. The British Association for Sexual Health and HIV (www.bashh.org/guidelines) provides information on the latest treatment trends.
Taking a sexual history
Before examining the various SAIs in more detail, it is necessary to consider the patient’s sexual history. This is an essential first step prior to screening a patient for SAIs. Obtaining a sexual history in the context of a sexual health centre is easier than with a general practitioner or family doctor. In the sexual health centre the patient is expecting to discuss sexual problems and infections. In a general practitioner or family doctor surgery, the patient might wish to discuss an embarrassing sexual problem but not know how to introduce it into the conversation. ‘I have a little problem down below’ can mean anything from genital warts to a prolapsed rectum. Conversely the patient attending a general practitioner or family doctor with a body rash might not understand why the doctor may wish to discuss their sexual history. This can be particularly uncomfortable if the doctor is seen as a family friend and may mean that the practice nurse needs to work in a more facilitative way and give the patient ‘permission’ to talk about intimate and possibly embarrassing issues. Also, the doctor’s or nurse’s own embarrassment may present an obstacle in identifying, treating and educating their patient about STIs (Box 35.1).
Box 35.1 Reflection
History taking
Human sexuality is complex and presumptions are often wrong. Do not assume that the patient is gay or straight; it is important to ask. Use open, inclusive questions when discussing the patient’s sexual activities. History taking needs to be systematic, incorporating questions appropriate for ascertaining risks and then provision of appropriate care. Consequently, whilst taking into account the individual patient, a sexual history should include the following questions (French 2007):
Parasitical infections
Scabies
The parasite Sarcoptes scabiei is a tiny skin mite that is almost impossible to see without a microscope. It causes a fiercely itchy skin condition known as scabies. Dermatologists estimate that more than 300 million cases of scabies occur worldwide every year. The disease can strike anyone of any race or age, poverty and over-crowding being more associated with the transmission of scabies than personal hygiene (McCarthy et al 2004).
Transmission
Human scabies is almost always contracted from close personal contact with someone who is already infested. Amongst adults the most common source of infection is a sexual partner (Walton & Currie 2007). Some people react more severely than others, and rarely an infected person may hardly itch at all. The mite is attracted to the warmth and odour of the body. The female mite is drawn to a new host, making a burrow, laying eggs and producing secretions that cause an allergic reaction. Larvae hatch from the eggs and travel to the skin surface, lying in shallow pockets where they will develop into adult mites. It may be 4–6 weeks before a newly infected person will notice the itching or swelling that can indicate the presence of scabies. In cases of reinfestation, established hypersensitivity may lead to symptoms within 1–3 days (Chosidow 2006).
Clinical presentation
Nursing management and health promotion: scabies
Crusted (Norwegian) scabies
Crusted or Norwegian scabies is caused by exactly the same mite as found in standard infestations, the main difference being simply the number of mites present on an infected person. In regular scabies, the number of mites on a host at any one time is, on average, 10–15 (with a range of 3–50). Persons with crusted scabies, on the other hand, will have thousands to millions of mites. Consequently their skin manifestations are much more severe, with thick, hyperkeratotic crusts that can occur on almost any area of the body. This form of scabies affects frail elderly people, often those in residential care, and patients who are immunosuppressed, such as those who are HIV positive (Johnston & Sladden 2005).
Nursing management and health promotion: crusted (Norwegian) scabies
As with all types of scabies, the patient’s household contacts and sexual contacts during the month prior to diagnosis will require treating. All household contacts will be required to take treatment at the same time. Crusted scabies can be treated with two doses of oral ivermectin, 2 weeks apart. The actual dosage required is dependent on body weight (Johnston & Sladden 2005).
Pediculosis
Clinical presentation
Nursing management and health promotion: pediculosis
Infestation with Pthirus pubis is on the whole a sexually transmitted infection, and 30% of these patients have a second STI. Therefore the nurse needs to bear in mind the need for a full sexual health screen (Varela et al 2003). If a patient has been infested with pubic lice they often feel ‘unclean’, particularly as the parasites are visible. The nurse needs to reassure the patient that the infestation, although easily acquired, is readily treatable and eradicable. It is important to remember that sexual partner(s) require treatment.
Candidiasis (vaginal thrush)
The causative organism is usually Candida albicans. Most women will have an episode in their lifetime. The yeast normally lives in the gut, mouth and genital tract, thriving in warm, moist and dark environments. The vagina can be considered an ideal environment for growth of this infection, since semen, menstrual blood, pregnancy and feminine hygiene products can all change the pH of the vagina. Some cultures resort to vaginal douches with home-made or proprietary preparations immediately after penetrative intercourse, in an attempt to prevent conception or infection. They are also used as a means of ‘improving’ feminine hygiene. This practice should be discouraged as it adversely affects the pH values of the vagina. Changes in pH create an imbalance that predisposes to the development of thrush. Additional risk factors include diabetes mellitus, hormone replacement therapy (HRT), the oral contraceptive, antibiotic therapy and immunodeficiency (Barousse et al 2004).
Trichomoniasis
Clinical presentation
Nursing management and health promotion: trichomoniasis
Diagnosis is by examination (the vaginal walls and cervix may be inflamed). A high vaginal swab is taken for culture, microscopy or, where available, a screening test known as latex agglutination (Adu-Sarkodie et al 2004). Treatment options include the antibiotic metronidazole, given to both partners over 5 days. This should be taken with food, and alcohol and sexual activity should be avoided during the treatment programme.
Bacterial sexually acquired infection
Bacterial vaginosis
This is a condition caused by overgrowth of the vaginal commensal microorganisms, associated with changes in the normal pH values of the vagina. If the mildly acidic environment of the vagina is subject to disturbance, the normal acid-producing lactobacilli of the vagina are supplanted by anaerobic bacteria. This initiates an increase in vaginal discharge and an increase in the pH of the vagina to above 4.5. Bacterial vaginosis (BV) may or may not be sexually transmitted; its aetiology remains unclear (Wilson 2004). The bacterium most associated with BV is Gardnerella vaginalis although it is suspected that several other organisms may be implicated. The presence of Gardnerella vaginalis does not necessarily mean the woman will be symptomatic (Smart et al 2004).
Clinical presentation
Nursing management and health promotion: bacterial vaginosis
On microscopic examination of vaginal secretions, characteristic clue cells can be seen. These are epithelial cells covered in a profusion of mixed bacteria which obscures the outline of the normally clearly delineated cell wall. In conjunction with the distinctive smell of BV, a raised vaginal pH value and the presence of the offensive discharge, clue cells help diagnose the presence of BV (Keane et al 2005).
There are potentially serious complications of BV. Its presence has been implicated in an increase in risk of acquiring and transmitting HIV as well as other SAIs such as Trichomonas vaginalis and chlamydia (Livengood 2009).
Chlamydia
Chlamydia is caused by the bacterium Chlamydia trachomatis. It is the most common sexually acquired infection in the UK (HPA 2009). It is particularly common in young, sexually active women (16–19 years). It is thought that younger women tend to have more sexual partners than older women and perhaps lack the skills and experience to negotiate safer sex, making them more vulnerable to infection. In men, the highest incidence of chlamydia is between the ages of 19 and 24.
Testing for chlamydia now involves the use of molecular biological tests to detect chlamydial DNA in urine and vaginal, cervical and vulval swabs. A national screening service for chlamydial infection was introduced in the UK during 2002 to 2003. This offers screening in non-traditional venues, in an effort to increase the number of participants. The screening programme has adopted non-invasive or self-administered tests involving urine samples and vaginal swabs (LaMontagne et al 2004).
Clinical presentation
The presentation in men includes:
Chlamydial infection leads to a number of major complications in women. These include pelvic inflammatory disease (PID), which can be defined as infection and resultant inflammation of the upper genital tract that may ascend to the fallopian tubes, ovaries and surrounding structures (Ross 2001). Commencing sexual activity under the age of 20, non-white ethnicity, and not having had children all increase the chances of developing PID (Simms et al 2006). PID can cause chronic pelvic pain and significantly increases the risk of ectopic pregnancy and infertility. Specific aspects of PID can include endometritis (infection of the lining of the womb) and even salpingitis (inflammation/infection affecting the uterine tubes). This is a consequence of ascending infection as described above and can cause acute abdominal pain. Long-term damage to pelvic organs can result, causing infertility.
In men, chlamydial infection can spread to the upper genital tract causing inflammation of the epididymis and testes (epididymo-orchitis) (Fenton et al 2001).
Nursing management and health promotion: chlamydia
Non-specific urethritis (NSU)
This condition only affects men. It is an inflammation of the urethra and is called ‘non-specific’ because there are a range of different causes, of which chlamydia is the most common. Other sexually transmitted infections may be implicated; there is increasing evidence that Mycoplasma genitalium is associated with this condition (Moi et al 2009). Urine and/or bladder infection may cause NSU, but this is quite unusual, particularly in younger men. Another cause is injury during sexual activity; the urethra is delicate and may be damaged during vigorous sexual activity, leading to NSU.
Gonorrhoea
Gonorrhoea is caused by the bacterium Neisseria gonorrhoeae, which infects the mucosal surfaces of the genital tract, rectum and oropharynx. The infection is always transmitted by sexual contact; however, eye infections can occur in infants during birth, and gonococcal vulvovaginitis in young girls can result from sexual abuse. The incubation period is around 24 h. Gonorrhoea is usually symptomatic within 3 days but can take up to 5 days. It is highly infectious. Currently gonorrhoea is most commonly seen in minority ethnic groups, homosexuals, women aged 16–19 and men aged 20–24. Uncomplicated gonorrhoea is the second most common bacterial SAI (HPA 2009).
Clinical presentation
Complications of gonorrhoea in men include formation of abscess, epididymitis, prostatitis and urethral strictures (see Ch. 8). Women may develop endometritis, ovarian abscesses, salpingitis and infertility, and bartholinitis (see Ch. 7). Gonorrhoea is diagnosed by microbiological examination of a swab of the discharge to identify the microorganism. In addition, patients should be screened for concurrent SAIs, especially chlamydia and trichomoniasis.
Nursing management and health promotion: gonorrhoea
In the past Neisseria gonorrhoeae proved sensitive to penicillin. However, as resistant strains of gonorrhoea have become more common, treatment options have evolved. A single dose of intramuscular ceftriaxone or oral cefixime is the treatment of choice (British Association for Sexual Health and HIV Clinical Effectiveness Group [BASHH] 2005). Single-dose treatments are used wherever possible as they overcome problems of non-compliance with medication regimens. Patients are asked to abstain from sexual activity until a second test confirms that treatment has been effective. The opportunity should be taken to advise patients about the use of condoms in preventing the spread of SAIs.
Lymphogranuloma venereum (LGV)
LGV is caused by specific sub-types of Chlamydia trachomatis that attack regional lymph nodes rather than mucocutaneous tissue, which is more usual. Until recent years, LGV was an almost forgotten infection in the industrially developed world. However, it remained endemic in Africa, the Caribbean and parts of Asia. Since 2004 there has been an increase of LGV in the industrialised West, in particular, although not exclusively, amongst men who have sex with men (MSM) (Ward & Miller 2009).
Clinical presentation
LGV is normally associated with inflammation of the inguinal lymph nodes with possible abscess formation. In the current resurgence of LGV amongst MSM, proctitis (an inflammation of the rectal mucosa) is often the presenting condition. Currently, in the Western world, LGV diagnosis appears to be closely associated with co-infection by HIV and other SAIs (Sethi et al 2009). If left untreated LGV may cause inguinal bubo (a highly inflamed, infected lymph node) with fistula formation and significant scarring.
Nursing management and health promotion: LGV
Nurses will need to ensure that patients understand the need to complete treatment, as a rather lengthy course (3 weeks) of oral doxycycline twice daily is required. Alternatively erythromycin may be used if a patient is allergic to doxycycline or pregnant (Klausner & Hook 2007). If a patient is diagnosed with LGV, it would be appropriate for the nurse to discuss HIV screening, given the association between the two infections.
Syphilis
Syphilis is a potentially lethal infection if left untreated and has a complex pattern of development (Box 35.2). Once thought to be in decline in industrialised countries, syphilis diagnoses have increased in recent years, generating concern (Simms et al 2005, Kerani et al 2007).
Box 35.2 Information
(from Brooker & Nicol 2003)
Clinical presentation
Tertiary (late) syphilis disease progression
Approximately 30% of untreated patients progress to the tertiary stage within 1–20 years. Clinically, this final stage may manifest as encapsulated, necrotic lesions known as gummata. Gummata are found in soft tissue or viscera and can also erode bony surfaces. As well as involving the skin and bones, tertiary syphilis may also attack the cardiac and central nervous systems causing cardiovascular and cerebral vascular damage (Box 35.3). Cardiovascular syphilis often involves the aortic arch, causing aortic incompetence or a saccular aortic aneurysm. The usual period in untreated syphilis from primary infection to development of the aneurysm is 10–15 years (Bossert et al 2004). Neurological manifestations of syphilis include meningovascular damage leading to strokes. In addition there may be the development of tabes dorsalis, a form of ataxia caused by syphilis attacking the neurological system, and possibly the development of general paresis (Goh 2005).
Congenital syphilis
The manifestation of early lesions in infants less than 2 years old is usually inflammatory and may involve the development of blisters on the skin, mucous membranes and bones. In addition the spleen and lymph glands may be inflamed. Haematological abnormalities may include thrombocytopenia and anaemia (see Ch. 11). The manifestation of late lesions in infants older than 2 years tends to be immunological and destructive. A chronic inflammation of the middle layers of the cornea known as interstitial keratitis may occur. Less commonly nerve deafness or developmental abnormalities of the teeth and long bones may be found.
Interaction between syphilis and HIV
The lesions associated with syphilis allow easier transmission of HIV. Syphilis and HIV infections commonly coexist and, in general, the clinical course is similar to non-HIV-infected patients. However, it has been suggested that in cases of co-infection with both syphilis and HIV, there is likely to be a higher viral load of HIV and a lower CD4 count (Buchacz et al 2004). The reasons why this should be are not fully understood; however, it has been demonstrated that successful treatment of syphilis is followed by a decrease in HIV viral load and a rise in the patient’s CD4 count (Kofoed et al 2006). In addition, in cases of co-infection the chancre of primary syphilis may be multiple and deeper than the classic presentation (painless and solitary) (Zetola et al 2007). Some research notes that the symptoms of secondary syphilis are on occasion more severe and neurosyphilis more likely (Lynn & Lightman 2004). In the vast majority of patients serological tests for syphilis are equally sensitive in both HIV-infected and non-infected persons. However, if clinical suspicion is high for syphilis and the serological tests are negative, biopsy of the lesion or rash is recommended.
Nursing management and health promotion: syphilis
In cases of co-infection, conventional therapy as given in syphilis alone is usually effective. However, some investigators believe in cases of co-infection, patients are more likely to present with or develop neurosyphilis and require a more intensive course of antibiotics (Goh 2005). The antibiotic chosen and duration of treatment depend on the disease stage: intramuscular procaine penicillin (or oral erythromycin if allergic to penicillin) or oral doxycycline and oxytetracycline are used. Patients having penicillin should be warned about the possibility of experiencing a Jarisch–Herxheimer reaction. This is characterised by fever, chills, nausea, muscle pain, dizziness and headache and is thought to be caused by toxins released when the microorganisms are destroyed (Pound & May 2005). The reaction occurs within a few hours of having the penicillin and is usually short-lived.
Viral sexually acquired infections
Genital herpes
This highly contagious viral disease is transmitted through close physical or sexual contact and is caused by the herpes simplex virus (HSV). Once acquired, HSV remains in the body, lying dormant within nerve roots. In most patients the virus intermittently works its way along the nerve root to the surface of the skin, where it may cause symptoms. There are two types of HSV, both of which infect the skin and mucous membranes: HSV-1 commonly causes cold sores, and HSV-2 infects the genital areas. In addition, HSV-1 is frequently the cause of genital herpetic lesions. If a person contracts HSV, they may be subject to repeated symptomatic episodes (Sen & Barton 2007).
Genital herpes is often asymptomatic; in fact, most cases are transmitted when the partner with HSV is symptom free (Box 35.4). The virus remains latent indefinitely and reactivation can be precipitated by multiple known and unknown factors which then induce viral replication. The efficiency of sexual transmission is greater from men to women than from women to men, although it is thought that the likelihood of transmission to others declines with increased duration of infection. The incubation period after acquisition is 2–12 days although the average is 4 days. Genital HSV infection will increase the risk of both acquisition and transmission of HIV infection.
Clinical presentation
Nursing management and health promotion: genital herpes
Systemic antiviral chemotherapy partially controls symptoms and signs of herpes episodes but does not eradicate latent virus. It does not affect the risk, frequency or severity of recurrences after the drug is discontinued. Systemic antiviral chemotherapy includes three oral medications: aciclovir, valaciclovir and famciclovir. Topical antiviral treatment has minimal clinical benefit and is not recommended (Sen & Barton 2007). Suppressive therapy, where the patient is given relatively low dosages of aciclovir, valaciclovir or famciclovir on a daily basis for a period of a year, is offered for recurrent genital herpes if a patient has more than six recurrences of episodic HSV in a year. It reduces frequency of recurrences and reduces but does not eliminate subclinical viral shedding. Periodically, at least once a year, the need for continued suppressive therapy should be reassessed.
As in the case of all sexual infections, patients should be assessed for their potential for behaviour change and prevention strategies should be discussed to develop an individualised risk-reduction plan. Prevention strategies include abstinence, mutual monogamy with an uninfected partner, use of condoms and limiting the number of sex partners. Nurses should also be aware that there is an intrinsic link between people contracting SAIs that produce genital ulceration, such as herpes and syphilis, and an increased risk of HIV (Freeman et al 2006).