Misoprostol(mye soe prost’ ole)
Cytotec, Novo-Misoprostol (CAN), PMS-Misoprostol (CAN)
PREGNANCY CATEGORY X
Drug Classes
Antiulcer agent
Prostaglandin
Therapeutic Actions
A synthetic prostaglandin E1 analogue; inhibits gastric acid secretion and increases bicarbonate and mucus production, protecting the lining of the stomach.
Indications
Prevention of NSAID (including aspirin)-induced gastric ulcers in patients at high risk of complications from a gastric ulcer (the elderly; patients with concomitant debilitating disease, history of ulcers)
With mifepristone as an abortifacient (see mifepristone)
Unlabeled uses: Appears effective in treating but not preventing duodenal ulcers in patients unresponsive to histamine-2 antagonists; cervical ripening and labor induction; postpartum hemorrhage; chronic idiopathic constipation
Contraindications and Cautions
Contraindicated with history of allergy to prostaglandins; pregnancy (abortifacient; advise women of childbearing age in written and oral form of use, have a negative serum pregnancy test within 2 wk prior to therapy, provide contraceptives, and begin therapy on the second or third day of the next normal menstrual period); lactation.
Use cautiously in the elderly, and with renal impairment, duodenal ulcers.
Available Forms
Tablets—100, 200 mcg
Dosages
Adults
200 mcg four times daily PO with food. If this dose cannot be tolerated, 100 mcg can be used. Take misoprostol for the duration of the NSAID therapy. Take the last dose of the day at bedtime.
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