Chapter 1 Medicines in society today and tomorrow
Medicines have an impact on the lives of people of all ages. In the main, the impact is beneficial, enhancing lifestyles and prolonging, and often saving, lives. However, in developing countries neither the benefits nor the hazards of modern drug therapy are experienced. Thanks to the innovative work of the global pharmaceutical industry, prescribers and their patients have access to a range of effective drugs and delivery systems that could scarcely be imagined when the NHS was established in 1948. The therapeutic explosion comes, however, with a hefty price tag for both the industry and the consumer. In developing a new drug, thousands of compounds are screened for therapeutic activity and safety. To bring a new drug to the market requires massive expenditure over a period of many years. The importance of the research and development effort involved to the global economy is vast. Pharmaceutical companies target their research efforts to those therapeutic areas in which the returns are likely to be profitable. One major drug can generate sales of billions of pounds per annum. The problem of research priorities remains unresolved, but the ultimate aim is to develop medicines designed to meet the needs of individual patients. Few resources can be diverted to finding treatments for very rare diseases, because of the low returns (profits) generated. Orphan drugs need to be adopted. Prescription medicines are vitally important, but it should not be forgotten that over-the-counter medicines play an important role in self-care, thus releasing resources for the NHS. By making some potent medicines available without prescription, access to medicines has been improved for those who can afford them. It is important that this deregulation is carried out within carefully defined conditions. Medicines are not just commodities; they are potent therapeutic agents that should be treated with the respect they merit.
Information technology will play an even more important role in both the discovery and the manage-ment of medicines. Electronic prescribing, automation and improved communications will all help to ensure that the benefits of modern drug therapy will be available to more people than ever before. Evidence-based prescribing decisions are increasingly being supported by IT. Delays in introducing an NHS-wide IT system are currently a cause for concern, as are the escalating costs of the system.
There is more attention given in the media to issues relating to drug use (legal and otherwise) than ever before. Bad news is reported more often than good. Newspapers have always been a source of information on drugs and medical research (Fig. 1.1). If the story involves sex, it is more likely to be reported than a story involving the overuse of vitamins.