Treatment of acute infections caused by sensitive strains of Streptococcus pneumoniae, Mycoplasma pneumoniae, Listeria monocytogenes, Legionella pneumophila; URIs, lower respiratory tract infections, skin and soft-tissue infections caused by group A beta-hemolytic streptococci when oral treatment is preferred to injectable benzathine penicillin; PID caused by Neisseria gonorrhoeae in patients allergic to penicillin; intestinal amebiasis caused by Entamoeba histolytica; infections in the newborn and in pregnancy that are caused by Chlamydia trachomatis and in adult chlamydial infections when tetracycline cannot be used; primary syphilis (Treponema pallidum) in penicillin-allergic patients; eliminating Bordetella pertussis organisms from the nasopharynx of infected individuals and as prophylaxis in exposed and susceptible individuals; superficial ocular infections caused by susceptible strains of microorganisms; prophylaxis of ophthalmia neonatorum caused by N. gonorrhoeae or C. trachomatis

Adjunct to antitoxin in infections caused by Corynebacterium diphtheriae and Corynebacterium minutissimum

Prophylaxis against alpha-hemolytic streptococcal endocarditis before dental or other procedures in patients allergic to penicillin who have valvular heart disease and against infection in minor skin abrasions

Treatment of peptic ulcer disease caused by Helicobacter pylori, in conjunction with clarithromycin

Unlabeled uses: Treatment of severe diarrhea associated with Campylobacter enteritis or enterocolitis; treatment of genital, inguinal, or anorectal lymphogranuloma venereum infection; treatment of Haemophilus ducreyi (chancroid); treatment of acne vulgaris and skin infections caused by sensitive microorganisms