Lisdexamfetamine Dimesylate(liss dex am fet’ a meen)
Vyvanse
PREGNANCY CATEGORY C
CONTROLLED SUBSTANCE C-II
Drug Classes
Amphetamine
CNS stimulant
Therapeutic Actions
Thought to block reuptake of norepinephrine and dopamine in the presynaptic neuron and increase release of these monamines into the extraneuronal space, stimulating CNS activity and leading to suppressed appetite, increased alertness, elevated mood, improved physical performance when fatigue and sleep deprivation have caused impairment; mode of action in attention deficit hyperactivity disorder (ADHD) is not understood.
Indications
Treatment of ADHD in patients 6 yr and older as part of an integrated treatment plan
Contraindications and Cautions
Contraindicated with hypersensitivity to any component of the drug, advanced arteriosclerosis, symptomatic CV disease, moderate to severe hypertension, hyperthyroidism, hypersensitivity or idiosyncratic reaction to sympathetic amines, glaucoma, agitated states, history of drug abuse, during or within 14 days following treatment with an MAOI, lactation.
Use cautiously with history of seizures, preexisting psychosis or bipolar disorder, pregnancy.
Available Forms
Capsules—20, 30, 40, 50, 60, 70 mg
Dosages
Adults and children 6 yr and older
30 mg/day PO in the morning; may increase at weekly intervals in increments of 10–20 mg/day to a maximum of 70 mg/day.
Pharmacokinetics
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Metabolism: Hepatic; T1/2: 1 hr
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