Leuprolide Acetate(loo proe’ lide)
Eligard, Lupron Depot, Lupron Depot-PED, Lupron Depot—3 Month, Lupron Depot—4 Month, Lupron Depot—6 Month, Lupron for Pediatric Use
PREGNANCY CATEGORY X
Drug class
Gonadotropin-releasing hormone (GnRH) analogue
Therapeutic Actions
An LH-RH agonist that occupies pituitary gonadotropin-releasing hormone receptors and desensitizes them; inhibits gonadotropin secretion when given continuously, leading to an initial increase, then profound decrease in LH and FSH levels.
Indications
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Advanced prostatic cancer—palliation, alternative to orchiectomy or estrogen therapy
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Depot only: Endometriosis
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Central precocious puberty
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Depot only: Uterine leiomyomata
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Unlabeled uses: Treatment of breast, ovarian, and endometrial cancers; infertility; prostatic hypertrophy
Contraindications and Cautions
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Contraindicated with allergy to leuprolide, pregnancy, undiagnosed vaginal bleeding, lactation.
Available Forms
Injection—5 mg/mL; Depot—3.75, 7.5 mg; Depot-Ped—7.5, 11.25, 15 mg; 3-mo Depot—11.25, 22.5, 45 mg; 4-mo Depot—30 mg, 72 mg; 6-mo Depot—45 mg; powder for injection—7.5 mg
Dosages
Adults
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Advanced prostate cancer: 1 mg/day subcutaneously; use only the syringes that come with the drug.Depot: 7.5 mg IM monthly (every 28–33 days). Do not use needles smaller than 22 gauge.3-mo depot: 22.5 mg IM or subcutaneously every 3 mo (84 days).4-mo depot: 30 mg IM or subcutaneously every 4 mo.6-mo depot: 45 mg subcutaneously every 6 mo.
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Endometriosis: 3.75 mg as a single monthly IM injection or 11.25 mg IM every 3 mo. Continue for 6 mo.
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Uterine leiomyomata: 3.75 mg as a single monthly IM injection for 3 mo or 11.25 mg IM once; give with concomitant iron treatment.
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