L

Laxatives

Uses

Short-term treatment of constipation; colon evacuation before rectal/bowel examination; prevention of straining (e.g., after anorectal surgery, MI); to reduce painful elimination (e.g., episiotomy, hemorrhoids, anorectal lesions); modification of effluent from ileostomy, colostomy; prevention of fecal impaction; removal of ingested poisons.

Action

Laxatives ease or stimulate defecation. Mechanisms by which this is accomplished include (1) attracting, retaining fluid in colonic contents due to hydrophilic or osmotic properties; (2) acting directly or indirectly on mucosa to decrease absorption of water and NaCl; or (3) increasing intestinal motility, decreasing absorption of water and NaCl by virtue of decreased transit time.

Bulk-forming: Acts primarily in small/large intestine. Retain water in stool, may bind water, ions in colonic lumen (soften feces, increase bulk); may increase colonic bacteria growth (increases fecal mass). Produces soft stool in 1–3 days.

Osmotic agents: Acts in colon. Similar to saline laxatives. Osmotic action may be enhanced in distal ileum/colon by bacterial metabolism to lactate, other organic acids. This decrease in pH increases motility, secretion. Produce soft stool in 1–3 days.

Saline: Acts in small/large intestine, colon (sodium phosphate). Poorly, slowly absorbed; causes hormone cholecystokinin release from duodenum (stimulates fluid secretion, motility); possesses osmotic properties; produces watery stool in 2–6 hrs (small doses produce semifluid stool in 6–12 hrs).

Stimulant: Acts in colon. Enhances accumulation of water/electrolytes in colonic lumen, enhances intestinal motility. May act directly on intestinal mucosa. Produces semifluid stool in 6–12 hrs.

◀ ALERT ▶ Bisacodyl suppository acts in 15–60 min.

Stool softener: Acts in small/large intestine. Hydrates and softens stools by its surfactant action, facilitating penetration of fat and water into stool. Produces soft stool in 1–3 days.

Laxatives

Name	Onset of Action	Uses	Side Effects/Precautions
Bulk-forming
Methylcellulose (Citrucel)	12–24 hrs up to 3 days	Treatment of constipation for postpartum women, elderly, pts with diverticulosis, irritable bowel syndrome, hemorrhoids	Gas, bloating, esophageal obstruction, colonic obstruction, calcium and iron malabsorption
Psyllium (p. 1017) (Metamucil)	Same as methylcellulose	Treatment of chronic constipation and constipation associated with rectal disorders; management of irritable bowel syndrome	Diarrhea, constipation, abdominal cramps, esophageal/colon obstruction, bronchospasm
Stool Softener
Docusate (p. 382) (Colace, Surfak)	1–3 days	Treatment of constipation due to hard stools, in painful anorectal conditions, and for those who need to avoid straining during bowel movements	Stomachache, mild nausea, cramping, diarrhea, irritated throat (with liquid and syrup dose forms)
Saline
Magnesium citrate (p. 734) (Citrate of Magnesia, Citro-Mag)	30 min–3 hrs	Bowel evacuation prior to certain surgical and diagnostic procedures	Hypotension, abdominal cramping, diarrhea, gas formation, electrolyte abnormalities
Magnesium hydroxide (p. 734)	30 min–3 hrs	Short-term treatment of occasional constipation	Electrolyte abnormalities can occur; use caution in pts with renal or cardiac impairment; diarrhea, abdominal cramps, hypotension
Sodium phosphate (Fleet Phospho-Soda)	2–15 min	Relief of occasional constipation; bowel evacuation prior to certain surgical and diagnostic procedures	Electrolyte abnormalities; do not use for pts with HF, severe renal impairment, ascites, GI obstruction, active inflammatory bowel disease
Osmotic
Lactulose (p. 666) (Kristalose)	24–48 hrs	Short-term relief of constipation	Nausea, vomiting, diarrhea, abdominal cramping, bloating, gas
Polyethylene glycol (p. 970) (MiraLax)	24–48 hrs	Short-term relief of constipation	Bitter taste, diarrhea
Stimulant
Bisacodyl (p. 140) (Dulcolax)	PO: 6–12 hrs Rectal: 15–60 min	Short-term relief of constipation	Elecrolyte imbalance, abdominal discomfort, gas, potential for overuse/abuse
Senna (p. 1094) (Senokot)	6–12 hrs	Short-term relief of constipation	Abdominal discomfort, cramps

Only gold members can continue reading. Log In or Register to continue

Share this:

• Click to share on Twitter (Opens in new window)
• Click to share on Facebook (Opens in new window)

Related

Related posts:

1. F
2. H
3. P
4. I

Stay updated, free articles. Join our Telegram channel

Join

Full access? Get Clinical Tree