Isosorbide Nitrates



Isosorbide Nitrates





(eye soe sor’ bide)


Isosorbide Dinitrate

Apo-ISDN (CAN), Dilatrate SRDNC, IsochronDNC, Isordil Titradose


Isosorbide Mononitrate

ImdurDNC, ISMO, Monoket

PREGNANCY CATEGORY C

PREGNANCY CATEGORY B

(IMDUR, MONOKET)


Drug Classes

Antianginal

Nitrate

Vasodilator


Therapeutic Actions

Relaxes vascular smooth muscle with a resultant decrease in venous return and decrease in arterial BP, which reduces left ventricular workload and decreases myocardial oxygen consumption.


Indications



  • Dinitrate: Treatment and prevention of angina pectoris


  • Mononitrate: Prevention of angina pectoris; treatment of angina pectoris (Monoket)


  • Unlabeled uses (dinitrate): Used with hydralazine in black patients with advanced heart failure; acute angle-closure glaucoma in emergent situations; achalasia


  • Unlabeled use (mononitrate): Used with nadolol to prevent recurrent variceal bleeding



Available Forms

Dinitrate: Tablets—5, 10, 20, 30, 40 mg; ER tabletsDNC—40 mg; SR capsulesDNC—40 mg; SL tablets—2.5, 5 mg

Mononitrate: Tablets—10, 20 mg; ER tabletsDNC—30, 60, 120 mg


Dosages

Adults

To avoid tolerance to drug, take short-acting products bid or tid with last dose no later than 7 PM and ER or SR products once daily or bid at 8 AM and 2 PM. This creates a nitrate-free period.

Isosorbide dinitrate

Jul 21, 2016 | Posted by in NURSING | Comments Off on Isosorbide Nitrates

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