Blood, the body fluid circulating through the heart, arteries, capillaries, and veins, consists of plasma and cellular components. The average male adult has about 5.5 L of blood, the average female 4.5 L. Plasma, the fluid portion, accounts for 55% of the blood volume and is composed of 92% water, 7% protein, and 1% inorganic salts; nonprotein organic substances such as urea; dissolved gases; hormones; and enzymes. Plasma proteins include albumin, fibrinogen, and globulins. Cellular components include erythrocytes (red blood cells [RBCs]), leukocytes and lymphocytes (white blood cells [WBCs]), and platelets. These cells are derived from pluripotent stem cells in the bone marrow, a process known as hematopoiesis (see Figure 26-1). Under normal conditions, only mature cells are found in circulating blood. The cellular components of blood account for 45% of the blood volume.
Characteristics of Cellular Components
Blood has multiple functions that are carried out by plasma or the cellular components (see Table 26-1, page 973).
Erythrocytes (RBCs)
Enucleated, biconcave disc.
Approximately 5 million erythrocytes per cubic millimeter of blood.
Cell contents consist primarily of hemoglobin, essential for oxygen transport. Whole blood contains 14 to 15 g of hemoglobin per 100 mL of blood.
Circulate about 115 to 130 days before elimination by reticuloendothelial system, primarily in spleen and liver.
Figure 26-1. Steps in differentiation of blood cells.
Approximately 5,000 to 10,000 leukocytes (WBCs) per cubic millimeter of blood.
Classified as granulocytes or mononuclear leukocytes.
Granulocytes account for about 70% of all WBCs; have abundant granules in cytoplasm; include neutrophils, basophils, and eosinophils.
Mononuclear leukocytes have single-lobed nucleus and granule-free cytoplasm; include monocytes and lymphocytes.
Platelets (Thrombocytes)
Approximately 150,000 to 450,000 platelets per cubic millimeter of blood.
Small particles without nuclei arise as a result of budding from giant cells (megakaryocytes) in bone marrow.
Primary function is to control bleeding through hemostasis.
Subjective and Objective Data
The patient who presents with a hematologic disorder may have a disruption of the hematologic, immune, or coagulation system, producing a diverse array of symptoms and physical examination findings. Patients commonly present with vague complaints of fatigue, frequent infections, swollen glands, and bleeding tendencies. Characterize these complaints and obtain a review of systems, concentrating on the neurologic, respiratory, cardiovascular, GI, genitourinary (GU), and integumentary systems to look for more clues of hematologic dysfunction. Perform a systematic physical examination, paying careful attention to the cardiovascular, respiratory, and integumentary systems.
Review of Systems
Skin and mucous membranes: Any bruises, infections, drainage, or bleeding from wound sites?
Neurologic: Any dizziness, tingling or numbness (paresthesia), headache, forgetfulness or confusion, difficulty walking (disturbance in gait), tiredness (fatigue), weakness?
Respiratory: Experiencing shortness of breath, especially on exertion?
Cardiovascular: Chest pain or feelings of funny heartbeats (palpitations)?
GI: Any bleeding from gums, abdominal pain, black stools, or blood-streaked vomit (emesis)? Any mouth sores, rectal pain, or diarrhea?
GU: Excessive menstrual flow? Any blood in urine or discomfort on urination?
Key History Questions
What are your present medications? Do you take over-thecounter (OTC) medications, vitamins, herbals, or nutritional supplements? What else have you taken in the past several months?
What medical problems have you had in the past? Any surgeries? Ask specifically about partial or total gastrectomy, splenic injury or splenectomy, tendency to bleed (eg, with dental procedures), infectious diseases, human immunodeficiency virus (HIV) infection, cancer.
What is your occupation? Ask about exposure to substances such as benzene, pesticides, and ionizing radiation.
Do you have a family history of hematologic or malignant disorder?
Determine the social history and lifestyle. Do you use illicit drugs or alcohol? What is your pattern of sexual activity?
Table 26-1 Functions of Blood
METHOD
INVOLVED
CELLS AND SUBSTANCES FUNCTION
Oxygen and carbon dioxide transport
Binding to hemoglobin; dissolved in plasma
• Erythrocyte • Hemoglobin • Plasma
Nutrient and metabolite transport
Bound to plasma proteins; dissolved in plasma
• Plasma proteins • Plasma
Hormone transport
In plasma
• Plasma
Transport of waste products to kidneys and liver
In plasma
• Plasma
Transport of cells and substances involved in immune reactions
Fever; tachycardia; abnormal breath sounds; delirium; oral lesions; erythema, swelling, tenderness, and drainage of the skin—suggest infection.
Laboratory Studies
Laboratory studies routinely done for patients with hematologic disorders include complete blood count (CBC), blood smear, and iron profile. Blood samples for these tests are most accurate when obtained by venipuncture (see Procedure Guidelines 26-1, pages 974 to 975).
Table 26-2 Characteristics of White Blood Cells
CELL
MAJOR FUNCTION
PHYSICAL CHARACTERISTICS
Neutrophi
Ingest and destroy microorganisms (phagocytosis)
Small cell, multilobed nucleus, most plentiful leukocyte
Eosinophi
Host resistance to helminthic infections; also allergic response
Bi-lobed nucleus; red-staining granules
Basophi
Allergic response
Bi-lobed nucleus; granules containing heparin and histamine
Monocyte
Phagocytosis
Large cell, kidneyshaped nucleus
B lymphocyte
Produce antibodies (immunoglobulins); humoral immunity
Small, agranular
T lymphocyte
Regulation of immune response; cellular immunity suppressor (T8)
Small, agranular; include cytotoxic, helper (T4) and T cells; identified by surface markers
Complete Blood Count
Description
Generally includes absolute numbers or percentages of erythrocytes, leukocytes, platelets, hemoglobin, and hematocrit in blood sample.
Erythrocyte (RBC) indices—can be done to provide information on the size, hemoglobin concentration, and hemoglobin weight of an average RBC; aids in diagnosis and classification of anemias.
Leukocyte (WBC) differential—can be done to determine the percentage of each type of granulocyte (neutrophils, eosinophils, and basophils) and nongranulocytes (lymphocytes and monocytes).
Absolute value of each is determined by multiplying the percentage by the total number of WBCs.
Used to evaluate infection or potential for infection and identify various types of leukemia.
Nursing and Patient Care Considerations
Blood sample can be drawn at any time without fasting or patient preparation.
Blood Smear
Description
Blood sample prepared for microscopic viewing using appropriate stains, allowing visual analysis of numbers and characteristics of cells; can identify abnormal cells of certain anemias, leukemias, and other disorders that affect the bloodstream.
PROCEDURE GUIDELINES 26-1
Obtaining Blood by Venipuncture
EQUIPMNT
Chlorhexidine-alcohol (if blood cultures will be obtained) or 70% alcohol
Dry sterile gauze pads
Vacutainer or syringe
20G needles or equivalent “needleless” supplies
Blood tubes
Disposable gloves
PROCEDURE
Nursing Action
Rationale
Performance phase
1. Reassure the patient. Explain that relatively little blood will be taken.
1. Allays anxiety and enlists cooperation.
2. Wash hands and put on gloves.
2. Universal precautions.
3. Instruct the patient to extend arm; the arm should be held straight at the elbow.
3. Exposes antecubital area.
4. Apply the tourniquet directly above the elbow (or targeted vein) with just sufficient pressure to prevent venous return.
4. Increases venous pressure and makes the vein more prominent and easier to enter.
5. Inspect the area to visualize the vein, including the antecubital area, wrist, dorsum (back) of hand, and top of foot (if necessary). Palpate the vein.
5. Select a vein that is visible, palpable, and well fixed to surrounding tissue so that it does not roll away. (Some veins may be deep and can only be palpated.)
6. Clean the skin with chlorhexidine-alcohol or alcohol. Allow to dry.
6. Sterile procedures.
7. Fix chosen vein with the thumb and draw the skin taut immediately below the site before inserting needle to stabilize the vein.
7. The vein may roll beneath the skin when the needle approaches its outer surface (especially in older and extremely thin patients).
8. Hold the syringe or Vacutainer between the thumb and last three fingers with the bevel of the needle up and directly in line with the course of the vein. Insert the needle quickly and smoothly under the skin and into the vein.
8. A pop may be felt as the needle enters the vein.
Key Decision Point If a pop is not heard, gently reposition the needle. |If a pop is still not heard, a hematoma becomes visible, or blood does not flow into tube when inserted into vacutainer, release the tourniquet and remove the needle. Try an alternate site.
9. Insert tube into Vacutainer and allow to fill. For syringe, gently pull back on the plunger until desired amount of blood is obtained.
9. Use minimal suction on syringe to prevent hemolysis of blood and collapse of the vein.
10. Release the tourniquet as soon as specimen is obtained, then remove tube from Vacutainer.
11. Withdraw the needle slowly.
11. Slow withdrawal of the needle is less painful.
12. Apply a dry sterile gauze pad to puncture site and request patient to apply gentle but firm pressure to site for 2.4 minutes.
12. Firm pressure over the puncture site prevents leakage of blood into surrounding tissues with subsequent hematoma development.
13. Make a blood smear from the needle, if ordered.
13. Physical characteristics of blood cells can be observed under the microscope.
14. If blood was obtained in a syringe, use needleless supplies per facility procedure and gently eject the blood sample into tubes.
14. Slow transfer of blood into the test tube without forming bubbles prevents hemolysis, which may alter results.
15. Invert the tube gently several times to mix blood with anticoagulant, if present.
15. For some tests, the blood is allowed to coagulate in the test tube.
16. Label samples correctly and send to laboratory immediately.
16. Samples should be sent to the laboratory with a minimum of delay for optimum reliability.
17. Dispose needle and syringe in appropriate containers to avoid possible spread of blood-borne viral diseases. Clean spills with 10% bleach solution. Remove gloves and wash hands.
17. Bleach will kill any pathogens, such as HIV.
Nursing and Patient Care Considerations
Can be done from blood sample drawn for CBC; no additional sample or patient preparation is necessary.
Iron Profile
Description
Test completed on blood sample that generally includes levels of serum ferritin, iron, total iron-binding capacity, folate, vitamin B12; used to determine type and severity of anemia.
Nursing and Patient Care Considerations
Recent administration of chloramphenicol, hormonal contraceptives, iron supplements, and corticotropin may affect results of serum iron and iron-binding capacity. No patient preparation needed.
Other Diagnostic Procedures
Bone Marrow Aspiration
Description
Aspiration of bone marrow from the iliac crest or (rarely) sternum to obtain specimen to examine microscopically and to perform a biopsy (see Procedure Guidelines 26-2, page 976).
Purposes include diagnosis of hematologic disorders; monitoring of course of illness and response to treatment; diagnosis of other disorders, such as primary and metastatic tumors, infectious diseases, and certain granulomas; and isolation of bacteria and other pathogens by culture.
Nursing and Patient Care Considerations
Give medication for pain and anxiety before or after the procedure, as ordered. A bone marrow aspiration with biopsy is more painful and may require use of mild to moderate sedation with appropriate monitoring.
Watch for bleeding and hematoma formation after procedure.
Lymph Node Biopsy
Description
Surgical excision or needle aspiration usually of a superficial lymph node in the cervical, supraclavicular, axillary, or inguinal region.
Performed to determine the cause of lymph node enlargement, to distinguish between benign and malignant lymph node tumors, and to stage metastatic carcinoma.
Nursing and Patient Care Considerations
Local anesthetic is usually given.
Specimen is placed in normal saline or 10% formaldehyde solution for transportation to the laboratory for cytologic and histologic evaluation.
GENERAL PROCEDURES AND TREATMENT MODALITIES
Splenectomy
The spleen is a fist-size organ located in the upper left quadrant of the abdomen. It includes a central “white pulp” where storage and some proliferation of lymphocytes and other leukocytes occurs and a peripheral “red pulp” involved in fetal erythropoiesis, and later in erythrocyte destruction and the conversion of hemoglobin to bilirubin. It may be surgically removed because of trauma or to treat certain hemolytic or malignant disorders with accompanying splenomegaly. A laparoscopic technique, usually with a lateral approach, is preferred to remove a normal to slightly enlarged spleen in benign conditions, such as idiopathic thrombocytopenic purpura, hemolytic anemia, or sickle cell disease. Compared to open surgery, laparoscopic splenectomies have a shortened hospital stay, decreased postoperative pain, and decreased risk of wound complications such as adhesions and infections.
Preoperative Management
For general aspects of preoperative nursing management, see Chapter 7.
Stabilization of preexisting condition:
For trauma: volume replacement with intravenous (IV) fluids, evacuation of stomach contents via nasogastric tube to prevent aspiration, urinary catheterization to monitor urine output, assessment for pneumothorax or hemothorax and possible chest tube placement.
For hemolytic or malignant disorder with accompanying thrombocytopenia: coagulation studies, administration of coagulation factors (eg, vitamin K, fresh-frozen plasma, cryoprecipitate), platelet and red cell transfusions.
Preoperative pulmonary evaluation and teaching.
For patient undergoing elective splenectomy, vaccination against pneumococcus, Haemophilus influenzae type B, and meningococcus are given at least 2 weeks before surgery.
PROCEDURE GUIDELINES 26-2
Bone Marrow Aspiration and Biopsy
EQUIPMENT
Bone marrow aspiration tray
Marrow aspiration needles with stylets
Towels
25G and 22G needles
Two 25-mL syringes
Three 5-mL syringes
Local anesthetic (1% procaine or lidocaine)
Sterile gauze squares
Sterile gloves, drape
Skin antiseptic
Masks and protective eyewear for physician and nurse (check your facility’s policy)
Laboratory equipment
Coverslips
Microscopic slides
Test tubes (plain and heparinized)
Scalpel blade and handle
PROCEDURE
Nursing Action
Rationale
1. Explain the procedure to the patient. Tell patient when the skin will be marked, antiseptic applied, and the needle puncture performed.
1. Allays anxiety and enlists cooperation. Tactile sensations (pressure, cold) can be misinterpreted as pain unless the patient is forewarned.
2. Give analgesic or tranquilizer, as requested, 30 minutes before procedure. May not be necessary for aspiration.
2. May minimize pain, discomfort, and anxiety during procedure.
3. Place the patient in prone or supine position for desired site:
3. Exposes desired site.
a. Posterior superior iliac crest—prone
b. Anterior iliac crest (if patient is very obese)—supine
Iliac Crest Aspiration/Biopsy
Performance phase (nurse assists)
1. If patient cannot tolerate prone position, assist patient to side-lying position with top knee flexed.
1.
a. The posterior iliac crest is located and marked.
a. The iliac crest provides a large marrow cavity at the posterior superior iliac spine away from nearby abdominal organs.
b. Tell the patient to expect a needle prick followed by a burning sensation. The periosteum is the region of greatest sensitivity.
b. The skin area is prepared and draped. The marked area is infiltrated with local anesthetic through the skin and subcutaneous tissue to the periosteum of the bone.
c. A small incision may be made.
c. The biopsy needle is large and a small incision facilitates insertion.
d. The bone marrow needle, with stylet in place, is introduced through the incision.
d. The needle is pointed toward the anterior superior iliac spine and brought into contact with the posterior iliac spine.
e. The needle is advanced and rotated by using firm and steady pressure. When the needle is felt to enter the outer cortex of the bone marrow cavity, the stylet is removed and the syringe attached. Negative pressure is applied and a small volume of blood and marrow is aspirated.
e. There is usually decreased resistance when the bone marrow cavity is entered. The actual aspiration may cause brief pain and the patient should be forewarned.
f. A biopsy is taken by using a special needle equipped with a sharp cutting edge and a hollow core.
f. Bone marrow appears rusty-red and normally has a thick, fluidlike consistency.
g. After removal of needle, apply pressure to site and dressing.
g. Prevents bleeding from puncture site. Dressing keeps site clean and dry until healed.
Postoperative Management
For general aspects of postoperative nursing management, see Chapter 7.
Prevention of respiratory complications: hypoventilation and limited diaphragmatic movement, atelectasis of left lower lobe, pneumonia, left pleural effusion.
Monitoring for hemorrhage.
Pharmacologic DVT prophylaxis, begun in operating room or if patient is at increased bleeding risk, as soon as bleeding risk subsides.
Administration of opioids for pain and observance for adverse effects.
Monitoring for fever.
Postsplenectomy fever—mild, transient fever is expected.
Persistent fever may indicate subphrenic abscess or hematoma.
Monitoring daily platelet count: thrombocytosis (elevation of platelet count) may appear a few days after splenectomy and may persist during first 2 weeks.
Potential Complications
Pancreatitis and fistula formation: tail of pancreas is anatomically close to splenic hilum.
Hemorrhage.
Atelectasis and pneumonia.
Overwhelming postsplenectomy infection (OPSI)—increased risk of developing a life-threatening bacterial infection with encapsulated organisms, such as Streptococcus pneumoniae, Neisseria meningitidis, or H. influenzae type b. The incidence of OPSI is 0.23% to 0.42% per year with a lifetime risk of 5%. An OPSI is a medical emergency and requires immediate IV antibiotics in an intensive care setting. IV immunoglobulins are also used.
NURSING ALERT
The risk of OPSI is highest soon after splenectomy and in patients whose splenectomy occurred during childhood or for a malignant disease. Early symptoms include fever and malaise; the infection may progress within hours to sepsis and death, with mortality as high as 50% to 70%. Patient education before and after splenectomy should include the risks of OPSI, recognition of early symptoms and prompt medical attention, MedicAlert bracelet, immunization against S. pneumoniae, H. influenzae type b, and N. meningitidis, and, in some cases, prophylactic and standby antibiotics.
Nursing Diagnoses
Ineffective Breathing Pattern related to pain and guarding of surgical incision.
Risk for Deficient Fluid Volume related to hemorrhage caused by surgery of highly vascular organ.
Risk for Injury (thromboembolism) related to thrombocytosis.
Risk for Infection related to surgical incision and removal of the spleen.
Acute Pain related to surgical incision.
Nursing Interventions
Maintaining Effective Breathing
Assess breath sounds and report absent, diminished, or adventitious sounds.
Assist with aggressive chest physiotherapy and incentive spirometry.
Encourage early and progressive mobilization.
Monitoring for Hemorrhage
Monitor vital signs frequently and as condition warrants.
Measure abdominal girth and report abdominal distention.
Assess for pain and report increasing pain.
Prepare patient for surgical re-exploration if bleeding is suspected.
Avoiding Thromboembolic Complications
Monitor platelet count daily, report abnormal result promptly.
Administer DVT prophylaxis, as ordered.
Assess for possible thromboembolism.
Assess skin color, temperature, and pulses.
Advise patient to report chest pain, shortness of breath, pain, or weakness.
Report signs of thromboembolism immediately.
Preventing Infection
Assess surgical incision daily or if increased pain, fever, or foul smell.
Maintain meticulous handwashing and change dressings using sterile technique.
Teach patient to report signs of infection (fever, malaise) immediately.
Educate patient and family regarding OPSI, including plan for postsplenectomy immunizations, recognition of symptoms, use of prophylactic and standby antibiotics.
Relieving Pain
Administer opioids or teach self-administration, as prescribed and as necessary, to maintain level of comfort.
Warn patient of adverse effects, such as nausea and drowsiness; watch for hypotension and decreased respirations.
Teach the use of nonpharmacologic methods, such as music, relaxation breathing, progressive muscle relaxation, distraction, and imagery to help manage pain.
Document dosage of medications and response to medication.
Make sure patient has analgesics for use postdischarge.
Patient Education and Health Maintenance
Teach care of incision.
Encourage to gradually increase activity according to guidelines given by surgeon.
Advise proper rest, nutrition, and stress avoidance while recovering from surgery.
Encourage follow-up as directed by surgeon and primary care provider to maintain immunizations.
Encourage patient to seek prompt medical attention for any infections and to contact health care provider immediately for high fever.
Evaluation: Expected Outcomes
Respirations unlabored, breath sounds clear.
Vital signs stable, abdominal girth unchanged.
Pulses strong, extremities warm and without pallor or cyanosis.
Afebrile, no purulent drainage from incision.
Verbalizes decreased pain.
ANEMIAS
Anemia is the lack of sufficient circulating hemoglobin to deliver oxygen to tissues. Anemia has multiple causes and is commonly associated with other diseases and disorders (eg, renal disease, cancer, Crohn’s disease, alcoholism). Anemia may be caused by inadequate production of RBCs, abnormal hemolysis and sequestration of RBCs, or blood loss. Iron-deficiency anemia, pernicious anemia, folic acid.deficiency anemia, and aplastic anemia are the anemias most commonly seen in adults. Hereditary hemolytic disorders include spherocytosis, hemoglobinopathies (eg, sickle cell), and enzymatic deficiencies such as glucose 6-phosphate dehydrogenase (G6PD). Treatments for anemia include nutritional counseling, supplements, RBC transfusions, and, for some patients, administration of exogenous erythropoietin (epoetin alfa or darbepoetin alfa), a growth factor stimulating production and maturation of erythrocytes. New erythropoiesis-stimulating agents are under development. Erythropoietin is used to stimulate RBC production in anemias associated with chronic renal failure, chemotherapy treatment, and HIV.
DRUG ALERT
Erythropoietic-stimulating agents, such as epoetin alfa and darbepoetin alfa, have been associated with increased risk of death and serious cardiovascular events. Use the lowest possible dose and monitor for such potential problems as hypertension— particularly in patients with chronic kidney disease—and deep venous thrombosis.
Iron-Deficiency Anemia (Microcytic, Hypochromic)
Iron-deficiency anemia is a condition in which the total body iron content is decreased below a normal level, affecting hemoglobin synthesis. RBCs appear pale and are small.
Pathophysiology and Etiology
The most common cause is chronic blood loss (GI bleeding including occult colorectal cancers, excessive menstrual bleeding, hookworm infestation), but anemia may also be caused by insufficient intake of iron (weight loss, inadequate diet), iron malabsorption (end-stage renal disease, smallbowel disease, gastroenterostomy), or increased requirements (pregnancy, periods of rapid growth).
Decreased hemoglobin may result in insufficient oxygen delivery to body tissues.
The incidence of iron-deficiency anemia, the most common type of anemia, varies widely by age, sex, and race. In the United States, it is more than twice as common in women as compared to men, affecting 10% of non-Hispanic white women and 20% of black and Hispanic women. It is a major health problem in developing countries.
Symptoms generally develop when hemoglobin has fallen to less than 11 g/100 mL.
Clinical Manifestations
Headache, dizziness, fatigue, tinnitus.
Palpitations, dyspnea on exertion, pallor of skin and mucous membranes.
In developing world: smooth, sore tongue; cheilosis (lesions at corners of mouth), koilonychia (spoon-shaped fingernails), and pica (craving to eat unusual substances).
Diagnostic Evaluation
CBC and iron profile—decreased hemoglobin, hematocrit, serum iron, and ferritin; elevated red cell distribution width and normal or elevated total iron-binding capacity (transferrin).
Determination of source of chronic blood loss may include sigmoidoscopy, colonoscopy, upper and lower GI studies, stools and urine for occult blood examination.
Management
Diagnosis and correction of chronic blood loss.
Oral or parenteral iron therapy.
Oral ferrous sulfate preferred and least expensive; treatment continues until hemoglobin level is normalized and iron stores replaced (up to 6 months).
Parenteral therapy may be used when patient cannot tolerate or is noncompliant with oral therapy. May use sodium ferric gluconate, iron sucrose, or iron dextran.
Complications
Severe compromise of the oxygen-carrying capacity of the blood may predispose to ischemic organ damage, such as myocardial infarction or stroke.
Anaphylaxis to parenteral iron therapy, especially with iron dextran.
Nursing Assessment
Obtain history of symptoms, dietary intake, past history of anemia, possible sources of blood loss.
Examine for tachycardia, pallor, dyspnea, and signs of GI or other bleeding.
Nursing Diagnoses
Imbalanced Nutrition: Less Than Body Requirements related to inadequate intake of iron.
Activity Intolerance related to decreased oxygen-carrying capacity of the blood.
Ineffective Tissue Perfusion related to decreased oxygen-carrying capacity of the blood.
Nursing Interventions
Promoting Iron Intake
Assess diet for inclusion of foods rich in iron. Arrange nutritionist referral, as appropriate.
Administer iron replacement, as ordered. Monitor iron levels of patients on chronic therapy.
RUG ALERT
Anaphylactic reactions may occur after parenteral iron administration. A test dose is required for iron dextran and recommended for iron sucrose or sodium ferric gluconate. Monitor patient closely for hypotension, angioedema, and stridor after injection. Do not administer with oral iron.
Increasing Activity Tolerance
Assess level of fatigue and normal sleep pattern; determine activities that cause fatigue.
Assist in developing a schedule of activity, rest periods, and sleep.
Encourage conditioning exercises to increase strength and endurance.
Maximizing Tissue Perfusion
Assess patient for palpitations, chest pain, dizziness, and shortness of breath; minimize activities that cause these symptoms.
Elevate head of bed and provide supplemental oxygen, as ordered.
Monitor vital signs and fluid balance.
Patient Education and Health Maintenance
Educate patient on proper nutrition and good sources of iron: select well-balanced diet that includes animal proteins, iron-fortified cereals and bread, beans, dried fruits, legumes, tofu (see Table 26-3). The daily requirement of iron for adult females age 19 to 50 is 18 mg, for men 8 mg; however, more is needed to build iron stores in those who have been anemic and for those who are at risk for anemia.
Teach patient about iron supplementation.
Take iron on empty stomach, with full glass of water or fruit juice.
Liquid forms may stain teeth; mix well with water or fruit juice and use a straw.
Anticipate some epigastric discomfort, change in color of stools to green or black, and, in some cases, nausea, constipation, or diarrhea. Prevent and treat constipation with increased fiber, fluids, and exercise. Report GI intolerance to health care provider.
Keep iron medications away from children as overdose may be fatal.
Encourage follow-up laboratory studies and visits to health care provider.
Table 26-3 Dietary Sources of Iron
FOOD
SERVING SIZE
MGPER SERVING
Cereal (fortified)
1 oz
1.8-21
Chicken liver
3.5 oz
12.8
Oatmeal (fortified)
1 cup
10
Soybeans
1 cup
8.8
Beef liver
3 oz
7.5
Lentils
1 cup
6.6
Beans (kidney, lima, navy, pinto)
1 cup
3.6-5.2
Oysters
6 pieces
4.5
Pumpkin seeds, roasted
1 oz
4.2
Beef (various cuts)
3-3.5 oz
2-3.9
Molasses
1 tbsp
3.5
Tofu
1/2 cup
3.4
Spinach, cooked
1/2 cup
3.2
Clams
3/4 cup
3.0
Sardines
3 oz
2.5
Turkey
3.5 oz
1.6-2.3
Macaroni (enriched, cooked)
1 cup
1.9
Bread (enriched)
2 slices
1.8
Rice (cooked)
1 cup
1.8
Apricots (dried)
10 pieces
1.7
Raisins
1/2 cup
1.5
Prune juice
1/2 cup
1.5
Pork
3.3.5 oz
1.2.1.5
Peas
1/2 cup
1.3
Chicken
3.3.5 oz
1.1.1.3
Evaluation: Expected Outcomes
Incorporates several foods high in iron into diet; takes prescribed iron supplementation, as ordered.
A megaloblast is a large, nucleated erythrocyte with delayed and abnormal nuclear maturation. Pernicious anemia is a type of megaloblastic anemia associated with vitamin B12 deficiency.
Pathophysiology and Etiology
Vitamin B12 is necessary for normal deoxyribonucleic acid synthesis in maturing RBCs.
Pernicious anemia demonstrates familial incidence related to autoimmune gastric mucosal atrophy.
Normal gastric mucosa secretes a substance called intrinsic factor, necessary for absorption of vitamin B12 in ileum. If a defect exists in gastric mucosa, or after gastrectomy or smallbowel disease, intrinsic factor may not be secreted and orally ingested B12 may not be absorbed.
Some drugs interfere with B12 absorption, notably ascorbic acid, cholestyramine, colchicine, neomycin, cimetidine, and hormonal contraceptives.
Lower-serum vitamin B12 concentrations are associated with aging, but the evidence linking subnormal vitamin B12 to anemia in older people remains limited and inconclusive.
Clinical Manifestations
Of anemia—pallor, fatigue, dyspnea on exertion, palpitations. May be angina pectoris and heart failure in older adults or those predisposed to heart disease.
Of underlying GI dysfunction—sore mouth, glossitis, anorexia, nausea, vomiting, loss of weight, indigestion, epigastric discomfort, recurring diarrhea or constipation.
Of neuropathy (occurs in high percentage of untreated patients)—paresthesia that involves hands and feet, gait disturbance, bladder and bowel dysfunction, psychiatric symptoms caused by cerebral dysfunction.
Diagnostic Evaluation
CBC and blood smear—decreased hemoglobin and hematocrit; marked variation in size and shape of RBCs with a variable number of unusually large cells.
Folic acid (normal) and B12 levels (decreased).
Gastric analysis—volume and acidity of gastric juice diminished.
Schilling test for absorption of vitamin B12 uses small amount of radioactive B12 orally and 24-hour urine collection to measure uptake—decreased.
Management
Parenteral replacement with hydroxocobalamin or cyanocobalamin (B12) is necessary by intramuscular (I.M.) injection from health care provider, generally every month.
Complications
Neurologic: paresthesia, gait disturbances, bowel and bladder dysfunction, and cerebral dysfunction may be persistent.
Nursing Assessment
Assess for pallor, tachycardia, dyspnea on exertion, exercise intolerance to determine patient’s response to anemia.
Assess for paresthesia, gait disturbances, changes in bladder or bowel function, altered thought processes indicating neurologic involvement.
Obtain history of gastric surgery or GI disease.
Nursing Diagnoses
Chronic Confusion related to neurologic dysfunction in absence of vitamin B12.
Impaired Comfort related to neurologic dysfunction in absence of vitamin B12.
Nursing Interventions
Improving Thought Processes
Administer parenteral vitamin B12, as prescribed.
Provide patient with quiet, supportive environment; reorient to time, place, and person, if needed; give instructions and information in short, simple sentences and reinforce frequently.
Minimizing the Effects of Paresthesia
Assess extent and severity of paresthesia, imbalance, or other sensory alterations.
Refer patient for physical therapy and occupational therapy, as appropriate.
Provide safe, uncluttered environment; make sure personal belongings are within reach; provide assistance with activities, as needed.
Patient Education and Health Maintenance
Advise patient that monthly vitamin B12 administration should be continued for life.
Instruct patient to see health care provider approximately every 6 months for hematologic studies and GI evaluation; may develop hematologic or neurologic relapse if therapy inadequate.
NURSING ALERT
Patients with pernicious anemia have higher incidence of gastric cancer and thyroid dysfunction; therefore, periodic stool examinations for occult blood, gastric cytology, and thyroid function tests should be done.
Evaluation: Expected Outcomes
Oriented, cooperative, and follows instructions.
Carries out activities without injury.
Megaloblastic Anemia: Folic Acid Deficiency
Chronic megaloblastic anemia is caused by folic acid (folate) defi-ciency.
Pathophysiology and Etiology
Dietary deficiency, malnutrition, marginal diets, excessive cooking of foods; commonly associated with alcoholism.
Impaired absorption in jejunum (eg, with small-bowel disease).
Increased requirements (eg, with chronic hemolytic anemia, exfoliative dermatitis, pregnancy).
Impaired utilization from folic acid antagonists (methotrexate) and other drugs (phenytoin, broad-spectrum antibiotics, sulfamethoxazole, alcohol, hormonal contraceptives).
Clinical Manifestations
Of anemia: fatigue, weakness, pallor, dizziness, headache, tachycardia.
Of folic acid deficiency: sore tongue, cracked lips.
Diagnostic Evaluation
Vitamin B12 and folic acid level—folic acid will be decreased.
CBC will show decreased RBC, hemoglobin, and hematocrit with increased mean corpuscular volume and mean corpuscular hemoglobin concentration.
Management
Oral folic acid replacement on daily basis.
Complications
Folic acid deficiency has been implicated in the etiology of congenitally acquired neural tube defects.
Nursing Assessment
Obtain nutritional history.
Monitor level of dyspnea, tachycardia, and development of chest pain or shortness of breath for worsening of condition.
Nursing Diagnosis
Imbalanced Nutrition: Less Than Body Requirements related to inadequate intake of folic acid.
Nursing Interventions
Improving Folic Acid Intake
Assess diet for inclusion of foods rich in folic acid: beef liver, peanut butter, red beans, oatmeal, broccoli, asparagus.
Arrange nutritionist referral, as appropriate.
Administer folic acid supplement.
Assist alcoholic patient to obtain counseling and additional medical care, as needed.
Community and Home Care Considerations
Encourage pregnant patient to maintain prenatal care and to take folic acid supplement.
Provide alcoholic patient with information about treatment programs and Alcoholics Anonymous meetings in the community.
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Key Decision Point
NURSING ALERT
DRUG ALERT
RUG ALERT
NURSING ALERT
