Genetics

1 Specify how the following disorders are usually transmitted genetically. The choices are autosomal dominant or recessive, X-linked recessive, chromosomal disorder, or polygenic disorder.

DISORDER	INHERITANCE PATTERN
von Willebrand disease	Autosomal dominant
Neurofibromatosis	Autosomal dominant
MEN I/II syndrome	Autosomal dominant
Achondroplasia	Autosomal dominant
Sphingolipidoses (Tay-Sachs disease, Gaucher disease)	Autosomal recessive
Fabry disease^∗	X-linked recessive
Mucopolysaccharidoses (e.g., Hurler disease)	Autosomal recessive
Hunter disease^†	X-linked recessive
Glycogen storage diseases (e.g., McArdle disease)	Autosomal recessive
Cystic fibrosis	Autosomal recessive
Marfan syndrome	Autosomal dominant
Huntington disease	Autosomal dominant
Pyloric stenosis	Polygenic disorder
Cleft lip/palate	Polygenic disorder
Type 2 diabetes	Polygenic disorder
Down syndrome	Chromosomal disorder (trisomy 21)
Familial hypercholesterolemia	Autosomal dominant
Galactosemia	Autosomal recessive
Amino acid disorders (e.g., phenylketonuria)	Autosomal recessive
Edward syndrome	Chromosomal disorder (trisomy 18)
Sickle cell disease	Autosomal recessive
Hemophilia	X-linked recessive
Glucose-6-phosphatase deficiency	X-linked recessive
Patau syndrome	Chromosomal disorder (trisomy 13)
Lesch-Nyhan syndrome	X-linked recessive
Obesity	Polygenic disorder
Neural tube defects	Polygenic disorder
Turner syndrome	Chromosomal disorder (XO)
Schizophrenia	Polygenic disorder
Duchenne muscular dystrophy	X-linked recessive
Wiskott-Aldrich syndrome	X-linked recessive
Bruton agammaglobulinemia	X-linked recessive
Fragile X syndrome	X-linked recessive
Children’s polycystic kidney disease	Autosomal recessive
Wilson disease	Autosomal recessive
Bipolar disorder	Polygenic disorder
Ischemic heart disease	Polygenic disorder
Alcoholism	Polygenic disorder
Hemochromatosis	Autosomal recessive
Adrenogenital syndrome (e.g., 21-hydroxylase deficiency)	Autosomal recessive
Familial polyposis coli	Autosomal dominant
Adult polycystic kidney disease	Autosomal dominant
Hereditary spherocytosis	Autosomal dominant
Tuberous sclerosis	Autosomal dominant
Myotonic dystrophy	Autosomal dominant