CHAPTER 23

Familial Malignant Melanoma

CHAPTER OBJECTIVES

• Distinguish between sporadic cutaneous malignant melanoma and familial malignant melanoma.
  
• Describe the etiology and various forms of familial malignant melanoma.
  
• Identify the risk factors associated with a predisposition to malignant melanoma.
  
• Discuss gene penetrance, variable expressivity, and skin phototype.
  
• Use clinical assessment tools at the bedside.
  
• Review the current surveillance, diagnosis, and treatment recommendations for familial malignant melanoma.

KEY TERMS

Computed tomography (CT) scan

Covariates

Head and neck squamous cell carcinoma

Lymph node mapping

Magnetic resonance imaging (MRI)

Melanomagenesis

Penetrance

Phototype

Positron emission tomography (PET) scan

Recurrent melanoma

Satellite moles

Sentinel node

Variable expressivity

Wide local excision

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