Etodolac(ee toe doe’ lak)
PREGNANCY CATEGORY C
Drug Classes
Analgesic (nonopioid)
NSAID
Therapeutic Actions
Inhibits prostaglandin synthesis by inhibiting the enzyme, cyclo-oxygenase.
Indications
Acute or long-term use in the management of signs and symptoms of osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis
Management of pain
Contraindications and Cautions
Contraindicated with significant renal impairment, pregnancy, lactation, hypersensitivity to aspirin, etodolac, or other NSAIDs.
Use cautiously with impaired hearing; allergies; hepatic, hypertension, and GI conditions.
Available Forms
Capsules—200, 300 mg; tablets—400, 500 mg; ER tablets—400, 500, 600 mg
Dosages
Adults
Osteoarthritis, rheumatoid arthritis: Initially, 600–1,000 mg/day PO in divided doses; maintenance ranges, 600–1,200 mg/day in divided doses. Do not exceed 1,200 mg/day. Patients less than 60 kg: Do not exceed 20 mg/kg. ER: 400–1,000 mg/day PO; adjust based on patient response. Do not exceed 1,200 mg/day.
Analgesia, acute pain: 200–400 mg every 6–8 hr PO. Do not exceed 1,200 mg/day.
Patients 6–16 yr
Juvenile rheumatoid arthritis: The daily dose (given as single dose, extended-release tablets) should be based upon body weight as follows:
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