Ethionamide(e thye on am’ ide)
Trecator
PREGNANCY CATEGORY C
Drug Classes
Antituberculotic (third line)
Therapeutic Actions
Bacteriostatic against Mycobacterium tuberculosis; mechanism of action is not known.
Indications
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TB—any form that is not responsive to first-line antituberculotics—in conjunction with other antituberculotics
Contraindications and Cautions
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Contraindicated with allergy to ethionamide, pregnancy.
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Use cautiously with hepatic impairment, diabetes mellitus, lactation.
Available Forms
Tablets—250 mg
Dosages
Adults
Always use with at least one other antituberculotic. 15–20 mg/kg/day PO up to a maximum 1 g/day; dosage may be divided if GI upset is intolerable. Concomitant use of pyridoxine is recommended to prevent or minimize the symptoms of peripheral neuritis. Alternative dosing: 250 mg/day PO; gradually titrate to optimal dose.
Pediatric patients
10–20 mg/kg/day PO in two or three divided doses after meals (not to exceed 1 g/day) or 15 mg/kg/24 hr as a single daily dose.
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