Entacapone(en tah kap’ own)
Comtan
PREGNANCY CATEGORY C
Drug Classes
Antiparkinsonian
Therapeutic Actions
Selectively and reversibly inhibits COMT, an enzyme that eliminates biologically active catecholamines, including dopa, dopamine, norepinephrine, epinephrine; when given with levodopa, entacapone’s inhibition of COMT is believed to increase the plasma concentrations and duration of action of levodopa.
Indications
Adjunct with levodopa and carbidopa in the treatment of the signs and symptoms of idiopathic Parkinson disease in patients who are experiencing “wearing off” of drug effects
Contraindications and Cautions
Contraindicated with hypersensitivity to drug or its component.
Use cautiously with hypertension, hypotension, hepatic or renal impairment, pregnancy, lactation.
Available Forms
Tablets—200 mg
Dosages
Adults
200 mg PO taken concomitantly with the dose of levodopa-carbidopa, a maximum of eight times/day (1,600 mg).
Pediatric patients
Safety and efficacy not established.
Pharmacokinetics
|
Stay updated, free articles. Join our Telegram channel
Full access? Get Clinical Tree
