Drugs
OVERVIEW
In this section, you’ll find a list of products that are considered drugs because their administration provokes a series of physiochemical events within the body. The drugs listed in this section each have unique actions, indications, and contraindications specific to the individual product. This information can also be found on the product’s package insert. The clinician holds responsibility for understanding how each of these products affects the cascade of wound-healing events.
Products listed in this section are reimbursed as prescription drugs. The clinician must contact the appropriate payor regarding specific payment information for a given drug.
Collagenase Santyl Ointment
Healthpoint Biotherapeutics
How supplied
Ointment: 15 g, 30 g
Action
Collagenase Santyl Ointment is a sterile enzymatic debriding ointment which contains 250 collagenase units per gram of white petrolatum USP. The enzyme collagenase is derived from the fermentation by Clostridium histolyticum. It possesses the unique ability to digest collagen in necrotic tissue.
Because collagen accounts for 75% of the dry weight of skin tissue, the ability of collagenase to digest collagen in the physiological pH and temperature range makes it particularly effective in the removal of detritus. Collagenase thus contributes to the formation of granulation tissue and subsequent epithelialization of dermal ulcers and severely burned areas. Collagen in healthy tissue or in newly formed granulation tissue isn’t attacked. No information is available on collagenase absorption through skin or its concentration in body fluids associated with therapeutic or toxic effects, degree of binding to plasma proteins, degree of uptake by a particular organ or in the fetus, and passage across the blood-brain barrier.
Indications
For debriding chronic dermal ulcers and severely burned areas
Contraindications
Contraindicated on patients who have local or systemic hypersensitivity to collagenase
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