DimenhyDRINATE(dye men hye’ dri nate)
Oral preparations: Apo-Dimenhydrinate (CAN), Dimetabs, Gravol (CAN), Triptone
Parenteral preparations: Dramanate, Dymenate
PREGNANCY CATEGORY B
Drug Classes
Anticholinergic
Antihistamine
Anti–motion-sickness drug
Therapeutic Actions
Antihistamine with antiemetic and anticholinergic activity; depresses hyperstimulated labyrinthine function; may block synapses in the vomiting center; peripheral anticholinergic effects may contribute to anti–motionsickness efficacy.
Indications
Prevention and treatment of nausea, vomiting, or vertigo of motion sickness
Unlabeled use: Treatment of nausea and vomiting of pregnancy.
Contraindications and Cautions
Contraindicated with allergy to dimenhydrinate or its components, lactation.
Use cautiously with narrow-angle glaucoma, stenosing peptic ulcer, symptomatic prostatic hypertrophy, bronchial asthma, bladder neck obstruction, pyloroduodenal obstruction, cardiac arrhythmias, pregnancy.
Available Forms
Tablets—50 mg; chewable tablets—50 mg; injection—50 mg/mL; liquid—12.5 mg/4 mL, 12.5 mg/5 mL; 15.62 mg/5 mL
Dosages
Adults
Oral
50–100 mg every 4–6 hr PO; for prophylaxis, first dose should be taken 30 min before exposure to motion. Do not exceed 400 mg in 24 hr.
Parenteral
50 mg IM as needed; 50 mg in 10 mL sodium chloride injection given IV over 2 min.
Pediatric patients 6–12 yr
25–50 mg PO every 6–8 hr, not to exceed 150 mg/day.
Pediatric patients younger than 6 yr
Only on advice of physician; not recommended.
Neonates
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