Dangerous Drug: Hydrocodone Bitartrate(hi droh koe’ done)
Zohydro ERDNC
PREGNANCY CATEGORY C
CONTROLLED SUBSTANCE C-II
Drug class
Opioid agonist analgesic
Therapeutic Actions
Acts as agonist at specific opioid receptors, with some specificity for mu receptors, in the CNS to produce analgesia, euphoria, sedation. The receptors mediating these effects are thought to be the same as those mediating the effects of endogenous opioids (enkephalins, endorphins).
Indications
Management of pain severe enough to require a continuous, around-the-clock analgesic for an extended period of time and for which alternative treatments are inadequate
Contraindications and Cautions
Contraindicated with hypersensitivity to hydrocodone or ingredients in the drug; significant respiratory depression, acute or severe bronchial asthma or hypercarbia, known or suspected paralytic ileus; pregnancy (readily crosses placenta; neonatal withdrawal); labor or delivery (opioids given to mother can cause respiratory depression in neonate; premature infants are at special risk; may prolong labor); acute alcoholism, breast-feeding.
Use cautiously with patients with addiction history; elderly, cachectic, or debilitated patients; head injuries; increased intracranial pressure; pulmonary disease; hepatic or renal impairment; gastric obstruction.
Available Forms
ER capsulesDNC—10, 15, 20, 30, 40, 50 mg
Dosages
Individualize dosage.
Adults
Initially, 10 mg PO every 12 hr for opioid-naïve or opioid-nontolerant patients. Increase in increments of 10 mg every 12 hr every 3–7 days to achieve adequate analgesia.
Geriatric patients or impaired adults
Use caution. Respiratory depression may occur in elderly or very ill patients and in those with respiratory problems. Titrate dosage slowly and use smallest effective dose while monitoring patient.
Patients with renal, hepatic impairment
May increase serum concentrations. Use smallest effective dose and monitor patient closely.
Pharmacokinetics
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Metabolism: Hepatic; T1/2: 8 hr
Distribution: Crosses placenta; enters breast milk
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