Dangerous Drug: Goserelin Acetate(goe’ se rel in)
Zoladex, Zoladex LA (CAN)
PREGNANCY CATEGORY X
PREGNANCY CATEGORY D
(IN BREAST CANCER)
Drug Classes
Antineoplastic
Hormone
Therapeutic Actions
An analogue of LH-RH or gonadotropin-releasing hormone; potent inhibitor of pituitary gonadotropin secretion; initial administration causes an increase in FSH and LH and resultant increase in testosterone levels; with long-term administration, these hormone levels fall to levels normally seen with surgical castration within 2–4 wk, as pituitary is inhibited. In women, this leads to a decrease in serum estradiol levels and therefore a reduction in ovarian size and function, uterus and mammary gland size, and a repression of sex hormone–responsive tumors.
Indications
Palliative treatment of advanced prostatic cancer when orchiectomy or estrogen administration is not indicated or is unacceptable
Stage B2–C prostatic cancer with flutamide for locally confined T2b–T4 carcinoma
Management of endometriosis, including pain relief and reduction of endometriotic lesions
Palliative treatment of advanced breast cancer in premenopausal and perimenopausal women
Endometrial thinning drug before endometrial ablation
Contraindications and Cautions
Contraindicated with pregnancy, lactation, hypersensitivity to LH-RH or any component, undiagnosed vaginal bleeding.
Use cautiously with hypercalcemia, high lipid levels.
Available Forms
Implant—3.6, 10.8 mg
