Cyproheptadine Hydrochloride(si proe hep’ ta deen)
PREGNANCY CATEGORY B
Drug Classes
Antihistamine (piperidine type)
Therapeutic Actions
Blocks the effects of histamine at H1 receptor sites; has atropine-like, antiserotonin, antipruritic, sedative, and appetite-stimulating effects.
Indications
Relief of symptoms associated with perennial and seasonal allergic rhinitis; vasomotor rhinitis; allergic conjunctivitis; mild, uncomplicated urticaria and angioedema; amelioraton of allergic reactions to blood or plasma; dermatographism; adjunctive therapy in anaphylactic reactions
Treatment of cold urticaria
Unlabeled uses: Treatment of vascular cluster headaches, appetite stimulation, treatment of nightmares associated with PTSD, prevention of vascular headaches such as migraines
Contraindications and Cautions
Contraindicated with allergy to any antihistamines, third trimester of pregnancy, newborns, preterm infants, elderly patients.
Use cautiously with narrow-angle glaucoma, stenosing peptic ulcer, symptomatic prostatic hypertrophy, asthmatic attack, bladder neck obstruction, pyloroduodenal obstruction, lactation.
Available Forms
Tablets—4 mg; syrup—2 mg/5 mL
Dosages
Adults
For initial therapy, 4 mg tid PO. For maintenance therapy, 4–20 mg/day in three divided doses PO; do not exceed 0.5 mg/kg/day.
Pediatric patients 7–14 yr
4 mg PO bid or tid; do not exceed 16 mg/day.
Pediatric patients 2–6 yr
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