Cyclobenzaprine Hydrochloride(sye kloe ben’ za preen)
Amrix, Apo-Cyclobenzaprine (CAN), Flexeril, Gen-Cyclobenzaprine (CAN), PMS-Cyclobenzaprine (CAN), ratio-Cyclobenzaprine (CAN)
PREGNANCY CATEGORY B
Drug Classes
Skeletal muscle relaxant (centrally acting)
Therapeutic Actions
Precise mechanism not known; does not directly relax tense skeletal muscles but appears to act mainly at brain stem levels or in the spinal cord.
Indications
Relief of discomfort associated with acute, painful musculoskeletal conditions, as adjunct to rest, physical therapy
Unlabeled use: Adjunct in the management of fibrositis syndrome
Contraindications and Cautions
Contraindicated with hypersensitivity to cyclobenzaprine, acute recovery phase of MI, arrhythmias, heart block or conduction disturbances, heart failure, hyperthyroidism.
Use cautiously with urinary retention, angle-closure glaucoma, increased IOP, lactation, mild hepatic impairment.
Available Forms
Tablets—5, 7.5, 10 mg; ER capsules—15, 30 mg
Dosages
Adults
5 mg PO tid, up to 10 mg PO tid. Do not exceed 30 mg/day; do not use longer than 2 or 3 wk. For ER capsules, 15 mg once/day; some patients need 30 mg/day.
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