Clindamycin(klin da mye’ sin)
Clindamycin Hydrochloride
Oral: Cleocin, Dalacin C (CAN)
Clindamycin Palmitate Hydrochloride
Oral: Cleocin Pediatric, Dalacin C Flavored Granules (CAN)
Clindamycin Phosphate
Oral, parenteral, topical dermatologic solution for acne, vaginal preparation: Cleocin Phosphate, Cleocin Phosphate IV, Cleocin T, Cleocin Vaginal Ovules, Clinda-Derm (CAN), Clindagel, ClindaMax, Clindesse, Dalacin C Phosphate (CAN), Dalacin Vaginal Cream (CAN), Dalacin T (CAN), Evoclin
PREGNANCY CATEGORY B
Drug Classes
Lincosamide antibiotic
Therapeutic Actions
Inhibits protein synthesis in susceptible bacteria, causing cell death.
Indications
Systemic administration: Serious infections caused by susceptible strains of anaerobes, streptococci, staphylococci, pneumococci; reserve use for penicillin-allergic patients or when penicillin is inappropriate; less toxic antibiotics (erythromycin) should be considered
Parenteral: Treatment of septicemia caused by staphylococci, streptococci; acute hematogenous osteomyelitis; adjunct to surgical treatment of chronic bone and joint infections due to susceptible organisms; do not use to treat meningitis; does not cross the blood–brain barrier.
Topical dermatologic solution: Treatment of acne vulgaris
Vaginal preparation: Treatment of bacterial vaginosis
Contraindications and Cautions
Systemic administration
Contraindicated with allergy to clindamycin, lactation.
Use cautiously in newborns and infants due to benzyl alcohol content (associated with gasping syndrome) and in patients with tartrazine sensitivity or hepatic or renal impairment.
Topical dermatologic solution, vaginal preparation
Contraindicated with allergy to clindamycin or lincomycin.
Use caution with history of regional enteritis or ulcerative colitis; history of antibiotic-associated colitis.
Available Forms
Capsules—75, 150, 300 mg; granules for oral solution—75 mg/5 mL; injection—150 mg/mL, 300 mg/2 mL, 600 mg/4 mL, 900 mg/6 mL; 300, 600, 900 mg/50 mL; topical gel—1%; topical lotion—1%; topical suspension—1%; vaginal cream—2%; vaginal suppository—100 mg
Dosages
Adults
Oral
150–300 mg every 6 hr, up to 300–450 mg every 6 hr in more severe infections.
Parenteral
600–2,700 mg/day in two to four equal doses; up to 4.8 g/day IV or IM may be used for life-threatening situations.
Vaginal
One applicator (100 mg clindamycin phosphate) intravaginally, preferably at bedtime for 7 consecutive days in pregnant women and 3 or 7 days in nonpregnant women; or insert vaginal suppository, preferably at bedtime for 3 days for Cleocin Vaginal Ovules.
Topical
Apply a thin film to affected area bid.
Pediatric patients
Oral
For clindamycin hydrochloride, 8–16 mg/kg/day (serious infections) or 16–20 mg/kg/day (more serious infections) in three or four equal doses. For clindamycin palmitate hydrochloride, 8–25 mg/kg/day in three or four equal doses; for children weighing less than 10 kg, use 37.5 mg tid as the minimum dose.
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