Citalopram Hydrobromide(si tal’ oh pram hi dro broh’ myde)
Apo-Citalopram (CAN)DNC, CelexaDNC, Co Citalopram (CAN)DNC, Gen-Citalopram (CAN)DNC, PMS-Citalopram (CAN)DNC, ratio-Citalopram (CAN)DNC
PREGNANCY CATEGORY C
Drug Classes
Antidepressant
SSRI
Therapeutic Actions
Potentiates serotonergic activity in the CNS by inhibiting neuronal reuptake of serotonin, resulting in antidepressant effect, with little effect on norepinephrine or dopamine reuptake.
Indications
Treatment of depression, particularly effective in major depressive disorders
Unlabeled uses: OCD, panic disorder, PMDD, social phobia, trichotillomania, PTSD, alcoholism, binge eating, third-line treatment of diabetic neuropathy, impulsive-aggressive behavior, irritable bowel syndrome, gambling, stuttering, tardive dyskinesia
Contraindications and Cautions
Contraindicated with MAOI use; allergy to drug or any component of the drug or other SSRIs; concomitant use of pimozide.
Use cautiously with renal or hepatic impairment, pregnancy, and lactation, patients with prolonged QT interval, patients predisposed to low potassium or low magnesium levels, and in patients who are elderly or suicidal.
Available Forms
TabletsDNC—10, 20, 40 mg; oral solution—2 mg/mL
Dosages
Adults
Initially, 20 mg/day PO as a single daily dose. If needed, after at least 1 wk, may be increased to 40 mg/day. Maximum daily dose, 40 mg/day (20 mg/day if also taking cimetidine or other CYP2C19 inhibitors).
Pediatric patients
Safety and efficacy not established.
Geriatric patients or patients with renal or hepatic impairment
20 mg/day PO as a single dose; increase to 40 mg/day only if clearly needed and patient is not responding.
Pharmacokinetics
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