Xanthelasma (Fig. 5-1; Plate 2), tendon xanthomas (cholesterol deposits in the skin, classically over tendons in the lower extremities), corneal arcus in younger patients, “milky”-appearing serum, and obesity are possible markers for familial hypercholesterolemia. Family members should be tested if a case of familial hypercholesterolemia is found. Pancreatitis in the absence of obvious risk factors may be a marker for familial hypertriglyceridemia.
Cholesterol
3 What physical findings will the Step 2 test use as clues to hypercholesterolemia?
4 What are the current recommendations for management of cholesterol levels?
NO CHD RISK FACTORS
≥2 CHD RISK FACTORS∗
KNOWN CHD/EQUIVALENT†
VERY HIGH RISK‡
INTERVENTION
LDL <160
LDL <100
LDL <100
LDL <70
None (meets goal)
LDL 160-189
LDL 100-129
LDL 70-99
Diet ± medications§
LDL ≥190
LDL ≥130
LDL ≥100
LDL ≥100
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