2 Caring for the patient with respiratory problems
ANATOMY AT A GLANCE
The basic structure of the respiratory system is summarized for you in Figure 2.1. Refer to this diagram whilst reading about the physiology in the next section.
PHYSIOLOGY YOU NEED TO KNOW
Pulmonary ventilation is the movement of air into and out of the lungs. It is carried out by increasing the volume of the thorax on inspiration thereby reducing pressure within the lungs to less than atmospheric. At rest this is accomplished by the diaphragm being lowered 1 cm which is sufficient to pull in some 500 mL of air. Exercise requires greater volumes of air to be inhaled. Contraction of the external intercostal and shoulder muscles further increases the volume of the thorax as the chest wall moves upwards and outwards, reducing pressure further and drawing larger volumes of air into the lungs. Expiration is a passive process of elastic recoil aided by the action of the internal intercostal muscles pulling the chest wall inwards during exertion.
External respiration is the gas exchange taking place within the alveoli. Oxygen diffuses across the very thin respiratory membrane of each alveolus from atmospheric air into the pulmonary capillaries. Carbon dioxide moves in the opposite direction. Both gases move down their partial pressure gradients.
Internal respiration. This term describes the movement of gases between the capillaries of the systemic circulation and tissue cells. This occurs by diffusion down partial pressure gradients with O2 entering cells and CO2 entering the capillaries.
Cellular respiration occurs within cells and involves the manufacture of adenosine triphosphate (ATP) within the mitochondria of the cell. ATP is the source of energy which drives cellular metabolism. Its manufacture requires glucose to enter the cell and be converted to pyruvic acid which is then fed into the Krebs Cycle, a complex piece of organic chemistry, to produce ATP. This can only operate in the presence of oxygen and produces water and carbon dioxide as waste products, which the cell has to dispose of.
Oxygen transport within the blood depends upon haemoglobin (Hb) which readily combines with oxygen molecules to form a molecule of oxyhaemoglobin. This molecule readily dissociates and releases oxygen molecules. When Hb has combined with all the oxygen it can it is said to be saturated. The degree of saturation of Hb is measured by a pulse oximeter and depends largely upon the amount of oxygen present in the blood as measured by its partial pressure. Oxygen saturation readings are therefore a good guide to the amount of oxygen available in the bloodstream and the aim should always be to keep them over 95%.
Carbon dioxide transport is more complex. Some CO2 is dissolved in plasma (7%) and some is attached to haemoglobin as carbaminohaemoglobin (23%). The remaining 70% is carried as bicarbonate ions (HCO3−) which combine with hydrogen ions in the lungs to form CO2 (exhaled) and H2O.
Blood pH reflects the degree of acidity of the blood as measured by the concentration of hydrogen ions. Arterial blood pH is normally in the range 7.35–7.45. A figure below that is called acidosis and if this is caused by respiratory problems such as CO2 retention, this is called respiratory acidosis. Metabolic acidosis indicates the cause is metabolic such as a diabetic ketoacidotic state.CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) (P337)
PATHOLOGY: Key facts
COPD is a term that covers several different diseases such as chronic bronchitis, emphysema and bronchiectasis. Patients are usually elderly and have a history of smoking for many years which has greatly contributed to the disease process. As the term COPD implies, the person is suffering from a slowly progressive airway obstruction which leads to a gradual deterioration in ventilation and gas exchange such that the person can no longer meet their body requirements for oxygen. Gradually respiratory failure develops.
Chronic bronchitis is caused by hyperactivity of the mucus secreting glands that line the bronchial mucosa. Overgrowth of the glands (hyperplasia) coupled with the increased volumes of secretions narrow the airway passages. Infection of retained secretions commonly leads to recurring chest infections. The original cause of the problem is mainly the irritants in cigarette smoke and possibly atmospheric pollution.
Emphysema involves the destruction of alveolar walls and elastic tissue. There is therefore a loss of lung volume available for gas exchange and compliance within the lung (the lung becomes ‘stiffer’). Cigarette smoke is the main cause. Emphysema and chronic bronchitis frequently occur in the same person and may be complicated by the presence of asthma (see below).
Bronchiectasis is a term used to describe abnormal dilation of the bronchi. In adults it is frequently caused by the accumulation of pus beyond a lesion which is obstructing a bronchus such as a bronchial carcinoma. It is seen in people with cystic fibrosis as a result of the accumulation of thick mucus and recurrent infections and may also be secondary to serious lung diseases such as suppurative pneumonia or pulmonary tuberculosis. Chronic inflammatory changes occur together with the accumulation of pus within the cavities that form leading to coughing, copious production of purulent sputum and a general deterioration in the patient’s condition.WHAT TO LOOK OUT FOR
Respiratory failure, therefore respiratory rate and depth should be carefully monitored along with other vital signs.
Level of consciousness as deteriorating respiratory function will lead eventually to cerebral hypoxia, confusion and disorientation.
Exercise tolerance and breathlessness should be monitored. Exercise tolerance gradually decreases with advancing disease to the point where even just walking across the room leaves the person breathless and distressed.PHARMACOLOGY FOCUS
Short-acting β2 agonists such as salbutamol and terbutaline are helpful for symptom relief. If symptoms are persistent in more serious cases then an antimuscarinic bronchodilator such as ipratropium will be used. This group of drugs are considered more effective in treating COPD than asthma. Antimicrobial therapy is discussed elsewhere, but generally amoxicillin is prescribed for exacerbations of chronic bronchitis.
PRIORITIES FOR NURSING CARE
Respiratory support involves helping the patient with an acute episode of breathlessness by positioning (sitting upright to maximize chest expansion) and coaching the patient in slower deeper respirations whilst providing psychological support. Close cooperation with the physiotherapist is essential to help with breathing exercises and pulmonary rehabilitation. Always check that oxygen cannulae are in place and are delivering the required flow rate.Stay updated, free articles. Join our Telegram channel
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