Breast Conditions



Breast Conditions





OVERVIEW AND ASSESSMENT


Subjective Data

Obtain a nursing history about specific breast complaints and general health information from the patient to plan care and appropriate patient teaching.


Breast Manifestations



  • Palpable lumps—date noted; affected by menstruation; changes noted since detection.


  • Nipple discharge—date of onset, color, unilateral or bilateral, spontaneous or provoked.


  • Pain or tenderness—localized or diffuse, cyclic or constant, unilateral or bilateral.


  • Date of last mammogram and result.


  • Patient’s practice of breast self-examination (BSE).



Physical Examination

Perform a breast examination, as outlined in Procedure Guidelines 23-1. Remind all women of the importance of routine checkups with breast examination. Although BSE is a first step in prevention of breast cancer, it has not been shown to be effective in reducing mortality. However, it does allow women to become more comfortable and familiar with their own bodies.


Guidelines for Early Detection



Women at Average Risk



  • Begin annual mammography at age 40. Annual clinical breast examination should be performed prior to mammography.


  • For women in their 20s and 30s, it is recommended that clinical breast examination be part of a periodic health examination, preferably at least every 3 years. Asymptomatic
    women age 40 and older should continue to receive a clinical breast examination as part of a periodic health examination, preferably annually.


  • Beginning in their 20s, women should be told about the benefits and limitations of BSE. The importance of prompt reporting of any new breast symptoms to a health care professional should be emphasized. Women who choose to do BSE should receive instruction and have their technique reviewed on the occasion of a periodic health examination.




Older Women



  • Screening decisions in older women should be individualized by considering the potential benefits and risks of mammography in the context of current health status and estimated life expectancy. As long as a woman is in reasonably good health and would be a candidate for treatment, she should continue to be screened with mammography.



Women at Increased Risk




  • Women at increased risk for breast cancer might benefit from additional screening strategies beyond those offered to women of average risk, such as earlier initiation of screening, shorter screening intervals, or the addition of screening modalities other than mammography and physical examination, such as ultrasound or magnetic resonance imaging (MRI).


  • Screening MRI is recommended for women with an approximately 20% to 25% or greater lifetime risk of developing breast cancer, including women with a strong family history of breast or ovarian cancer and women who were treated for Hodgkin’s disease. Other women at high risk include those over the age of 35 with a 5-year risk of invasive breast cancer >1.7% risk per the Gail model, women with a history of LCIS and atypical hyperplasia, and those with a prior history of breast cancer. Annual MRI should be considered in these women. The Gail model is available on the National Cancer Institute website at www.cancer.gov or at www.breastcancerprevention.com.


Laboratory Tests


Nipple Discharge Cytology


Description

Secretions are smeared on a slide, fixed, and submitted for cytologic examination. There is a high rate of false-negative test results with this method.


Nursing and Patient Care Considerations



  • Wash nipple area with water and pat dry before obtaining specimen if crusting of drainage is present.


  • Gently milk breast or ask woman to express fluid to obtain a large drop on nipple.


  • Carefully touch slide to drop and draw slide across nipple to obtain smear. Spray with fixative or drop into container with fixative.


  • Inform patient of results promptly to reduce anxiety and explain that other tests may be needed.


Ductal Lavage


Description

A procedure that targets asymptomatic women at increased risk for breast cancer. Breast duct epithelial cells are collected from the nipple for cytological analysis.



Nursing and Patient Care Considerations

Advise patient to discuss questions with health care provider. This test is not widely used and there is insufficient data at this time to recommend its use for screening.


Additional Laboratory Tests


Tumor-Specific Tests

Tests to evaluate the characteristics of a tumor and/or its potential to regrow.



  • Estrogen and progesterone receptors identify patients most likely to benefit from hormonal forms of therapy. Approximately 75% are estrogen receptor positive. A negative result is associated with a less favorable prognosis.


  • HER2—human epidermal growth factor receptor that has been demonstrated in 15% to 30% of breast cancers. Found by many investigators to be associated with poorer survival, regardless of clinical stage. May affect treatment decisions.


  • Histologic grade is reported using an Elston-Ellis modification of the Scarf-Bloom Richardson Scale. It is a combination of nuclear grade, mitotic rate, and tubule formation with scores given for each. A low score equates to a low grade (grade I), and a higher score to a higher grade (grade III). In general, high-grade tumors are more likely to recur when compared to low-grade tumors.


  • Multiparameter gene assays (eg, Oncotype DX and MammaPrint) quantify the likelihood of distant breast cancer recurrence and measure how chemotherapy may assist with planning treatment. The OncotypeDX assay is included in the National Comprehensive Cancer Network guideline treatment decision pathway. A similar assay for ductal carcinoma in situ (DCIS) is under investigation. Breast cancer diagnostic and treatment guidelines are available at www.nccn.org.


  • Cancer subtyping—as determined by gene expression profiling—is currently under investigation.


  • Pathologists may use other special stains to aid in diagnosis.


Tests to Detect Metastasis



  • Increased values on liver function tests may indicate possible liver metastasis.


  • Increased calcium and alkaline phosphatase levels may indicate possible bony metastasis.


  • Additional metastatic workup may include chest x-ray, bone scan, computed tomography (CT) scan, and positron emission tomography (PET) scan.


  • Biological markers (ie, CA15-3 and CA27.29) may be used for monitoring patients with metastatic disease in conjunction with diagnostic imaging, history, and physical examination. Present data are insufficient to recommend their use alone for screening, diagnosis, or staging. However, they may be used to indicate treatment failure.


Radiology and Imaging


Mammography


Description



  • Low-dose x-ray of breast used to screen for breast abnormalities or may be used when a lump is found on physical examination. Can detect patients with clustered microcalcifications.


  • Compression of the breast is used to reduce the amount of radiation absorbed by the breast tissue and separate overlapping tissue.


  • Two views are taken routinely: craniocaudal and mediolateral; other views are done as necessary.


  • Best performed at a facility that is accredited by the American College of Radiology. The machines and staff at these facilities have met specific criteria. Computer-aided detection has been developed to aid radiologists in detecting abnormalities. Assessment categories have been developed to describe the results and provide follow-up recommendations.



    • Category 1 is a negative result (normal mammogram) with nothing on which to comment.


    • Category 2 is a normal mammogram but there is a benign finding on which to comment.


    • Category 3 is probably benign, but short interval follow-up may be recommended to determine stability of the finding.


    • Category 4 describes a suspicious abnormality and biopsy should be considered.


    • Category 5 is highly suggestive of malignancy requiring appropriate action.


    • Category 6 describes a known, biopsy-proven malignancy requiring appropriate action.


  • Mammography is not routinely done if a woman is pregnant.


  • The breasts of young women tend to be extremely dense and are poorly suited to mammography.


  • False-negative results occur even in the best facilities; figure may reach 10%.


  • Both screen film and digital mammography use x-rays to obtain images. With digital mammography, a film image is replaced with an electronic image similar to digital photography. For younger women under age 50, women with radiographically dense breasts, and premenopausal and perimenopausal women, digital mammography is more accurate than film mammography. For all other women, there is no significant advantage to using digital mammography.



Nursing and Patient Care Considerations



  • Recommend regular screening based on established guidelines (see page 884). Tell patients that routine screening mammography has been shown to reduce mortality from breast cancer. Procedure takes approximately 15 minutes.


  • Remind patients not to apply deodorant, cream, or powder to breast, nipple, or underarm areas on examination day.


  • Advise that some discomfort may be felt from compressing the breast.


  • Patients should have an opportunity to become informed about the benefits, limitations, and potential harms associated with regular screening. Overdiagnosis of clinically insignificant disease is possible. Benefits are thought to outweigh the exposure to low dose of radiation.


  • Alert patient that extra views do not imply that the patient has breast cancer.




Ultrasonography


Description



  • Uses high-frequency sound waves to get an image of the breast.


  • Helps determine if a lump is a cyst or a solid mass.


  • May be used if patient is pregnant or is younger than age 35.


Nursing and Patient Care Considerations



  • Advise that this test is painless and noninvasive.


  • No preparation is necessary.


Additional Imaging Studies


Galactography/Ductogram



  • A contrast mammogram is obtained by injection of water-soluble contrast medium into a duct for patient with persistent bloody nipple discharge. It is a time-consuming procedure that is not routinely used.


  • It may outline an intraductal papilloma.


  • Its ability to differentiate benign from malignant lesions is limited.


  • Other tests such as tomosynthesis (3D mammography) and thermography may be useful in some women; however, these are not often used.


Magnetic Resonance Imaging



  • Produces images from the combination of a magnetic field, radio waves, and computer processing.


  • May be used in newly diagnosed breast cancer patients for presurgical planning. May help in determining extent of disease, multifocality, and unsuspected disease in the contralateral breast.


  • Useful in high-risk women, those with dense breasts, and in those with silicone implants.


  • Because MRI is less accessible and more expensive than mammography, it is not useful for generalized screening. There may be increased false-positive results. MRI-guided biopsy is not widely available.


  • See page 206 for description of MRI.


Other Tests

In addition to laboratory tests and imaging studies, biopsy methods are commonly used to evaluate breast conditions. A biopsy is the only certain way to learn whether a breast lump or suspicious area seen on a mammogram is cancerous.


Fine-Needle Aspiration


Description



  • Uses a thin needle and syringe to collect tissue or to drain lump after using a local anesthetic. If it is a cyst, removing the fluid will collapse it; no other treatment may be needed. Ultrasound may be used to locate a nonpalpable cyst.


  • Normal cyst fluid appears straw-colored or greenish. Fluid should be sent for cytology if it appears suspicious (clear or bloody); otherwise, it is discarded.


  • This office procedure uses local anesthetic with results usually within 24 hours.


  • It has limited sensitivity, possibly because of insufficient acquisition of cytologic material.


Nursing and Patient Care Considerations



  • Inform patient of small risk of hematoma and infection.


  • Adhesive bandage applied after procedure; usually no discomfort.


  • Solid lesions may warrant an excisional biopsy.


Needle Biopsy


Description



  • Office procedure uses local anesthetic and removes a small piece of breast tissue using a needle with a special cutting edge.


  • For palpable lesions with a high suspicion of malignancy. May provide a tissue diagnosis quickly—usually approximately 24 hours—without doing an excisional biopsy to plan definitive surgery.


  • Ultrasound guidance may be used for nonpalpable lesions.


Nursing and Patient Care Considerations



  • Inform patient of small risk of hematoma and infection.


  • Tell patient that several passes may be necessary to obtain specimen, with minor discomfort.


  • Pressure dressing applied after procedure.


  • Recommend use of acetaminophen or ibuprofen for postprocedure discomfort—usually minimal, if any.


Stereotactic Core Needle Biopsy


Description



  • An x-ray-guided method for localizing and sampling nonpalpable lesions detected on mammography with 90% to 95% sensitivity in detecting breast cancer.


  • Performed as an outpatient procedure with the patient lying prone on a special table using an automated biopsy gun with a vacuum system to draw tissue into a sampling chamber and rotate cutter to excise tissue.


  • After local anesthetic is administered, a needle is placed in the lesion with confirmation of its position on stereotactic x-ray views. Multiple samples are taken from different portions of the lesion. Allows harvesting of larger quantities of tissue with a single needle insertion. A tiny clip may be left in place at the end of the procedure to mark the area.


  • The procedure is quicker and less expensive than mammographically guided needle localization followed by surgical excisional biopsy and is an alternative to surgical excisional biopsy to make a diagnosis.


Nursing and Patient Care Considerations



  • Inform patient that it is a 1-hour outpatient procedure that requires no special preparation.


  • The patient should dress comfortably and will need to remain still during the procedure.



  • Complications may include minor bleeding, hematoma, and infection.


  • Explain that nonspecific, suspicious, or atypical findings may result in proceeding to excisional biopsy.


  • Remind patient that area in question will not be removed, only sampled.

    Note: Many nonpalpable abnormalities that require breast biopsy are being identified because of increased use of screening mammography.


Excisional Biopsy


Description



  • Surgical removal of a palpable or nonpalpable lesion. A frozen section may be done for immediate tissue diagnosis.


  • Excisional biopsy or lumpectomy entails entire removal of a mass; incisional biopsy entails partial removal of a mass.


  • This outpatient procedure may be performed under local or general anesthesia.


  • Curvilinear incision is usually made directly over the mass, which is excised en bloc including a 1-cm grossly free margin of tissue.


Nursing and Patient Care Considerations



  • Pressure dressing is placed, which can be removed in 24 to 48 hours.


  • Inform patient to watch for bleeding, hematoma, and signs of infection.


  • Recommend analgesics for discomfort and a support bra for comfort.


  • May take several days to get results, a stressful time for patients.


Needle Localization with Biopsy


Description



  • Performed when there is a nonpalpable mammographic finding.


  • Mammogram is used as a guide for placing a needle at the site of the breast change after injecting some local anesthetic.


  • A wire may be left in place for the surgeon and dye may be injected to mark the site.


  • Excisional biopsy is then done (see above) removing the area around the tip of the wire.


Nursing and Patient Care Considerations

Inform patient that this may be a tedious procedure because she must remain immobile while the breast is compressed in the mammogram machine and different views are obtained.


Sentinel Lymph Node Biopsy


Description



  • A diagnostic surgical procedure utilizing selective lymph node sampling.


  • Pathologic study of the first (sentinel) axillary lymph node to receive drainage from a tumor; predicts the status of the remainder of the lymph nodes in the axilla.


  • Localization accomplished by injection of a blue dye and/or radioactive particles around a tumor to identify lymph nodes with afferent drainage.


  • The excised sentinel lymph nodes are subjected to routine pathologic examination and, possibly, immunohistochemical staining to detect micrometastasis.


  • The status of the sentinel lymph node is used to determine whether to proceed with full axillary dissection and/or determine treatment modalities.


  • If the sentinel lymph node tests negative, no further axillary surgery is indicated.


  • If test result is positive, further axillary dissection may be needed. There is currently debate regarding optimal treatment for node-positive disease in women undergoing breastconserving surgery and having fewer than three involved lymph nodes. The omission of completion axillary lymph node dissection in selected patents has increased with no difference in overall survival. There are no clear-cut guidelines at this time.


Nursing and Patient Care Considerations



  • This is a reliable procedure, which is usually performed at the same time as definitive surgery—in conjunction with a breast-preserving procedure or mastectomy.


  • There is less morbidity and cost than with axillary dissection.


GENERAL PROCEDURES AND TREATMENT MODALITIES


Breast Self-Examination

Breast self-examination (BSE) is an inexpensive, risk-free method to detect cancer. When lumps are discovered at an early stage, patients have a better chance for long-term survival (see Patient Education Guidelines 23-1, page 890).


Patient Education


General Points to Emphasize



  • Examine breasts once per month, just after the menstrual period because breasts are less engorged and a tumor is easier to detect, and at regular monthly intervals after the cessation of menses.


  • Compare findings with the opposite breast.


  • Remind patient that 90% of breast lumps are not cancerous.


  • Do not neglect men when teaching BSE—1% of breast cancers occur in men.


  • It is acceptable for women to choose not to do BSE or to do BSE irregularly.



Suggestions for Patients Who Find BSE Difficult



  • Tenderness—gentle self-examination may be more effective and less painful than examination by someone else.


  • Cystic breasts—recommend professional examination annually, and instruct patient to compare changes in breasts from one month to the next.


  • Large, pendulous breasts—encourage woman to support her breast with her hand to palpate thoroughly; lying down may help to flatten breasts.




Community Health Education

Implement patient teaching of BSE on a community level by:



  • Teaching BSE to women in the community—schools, churches, women’s groups.


  • Reinforcing that early detection is associated with decreased mortality.


  • Helping patients and families establish and maintain support networks.


  • Tailoring patient education messages to patients of different cultures.


  • Knowing the resources available and making people aware of them.



    • National Cancer Institute—answers questions and provides booklets about cancer. Call 800-4-CANCER or go to www.cancer.gov.


    • American Cancer Society—offers many services to patients and their families. Call 800-ACS-2345 for local chapter or go to www.cancer.org.


Surgery for Breast Cancer

Surgery for breast cancer may involve mastectomy or a breast-preserving procedure. The objective of breast-preserving procedures is a cosmetically acceptable breast after complete excision of the tumor. Research studies that compare breast conservation with mastectomy have demonstrated equivalent patient survival. Contraindications to breast conservation include multifocal disease; diffuse, extensive DCIS; inability to tolerate radiation therapy; and persistent positive margins. The evolving field of oncoplastic surgery uses techniques to allow the removal of large volumes of breast tissue while avoiding deformity. Although mastectomy rates have remained stable, risk-reducing contralateral prophylactic mastectomy has risen. See Table 23-1 for the surgical approach options that are available. The following discussion covers mastectomy and axillary node dissection.


Preoperative Management

See Chapter 7 for routine preoperative care. In addition:









Table 23-1 Types of Surgery for Breast Cancer









































PROCEDURE


DESCRIPTION


INDICATIONS


Tumor ablation


Insertion of probe that destroys cancer cells by heating or freezing


Done in research setting for some localized breast cancers.


Lumpectomy (excisional biopsy)


Removal of tumor and surrounding tissue


For diagnosis of an abnormal mammographic finding or palpable breast lump if needle biopsy not performed. Further surgery may be needed.


Quadrantectomy (partial mastectomy)


Removal of a breast quadrant that includes the tumor area and possibly overlying skin


Normal- to large-sized breasts. Usually done at the same time as axillary surgery.


Sentinel lymph node biopsy


Removal of only a few gatekeeper lymph nodes


Performed to predict status of lymph nodes—if negative for tumor, axillary dissection is not performed. May be done in conjunction with quadrantectomy or mastectomy.


Axillary dissection


Surgical removal of the axillary lymph nodes


Performed when lymph node is positive for tumor, mainly for prognosis, staging, and local/regional disease control.


Simple mastectomy*


Surgical removal of the entire breast


Large or multifocal tumors; women with very small breasts in whom local excision of tumor will be cosmetically unacceptable; ineligibility for radiation therapy; patient preference; prophylaxis.


Modified radical mastectomy*


Surgical removal of the entire breast and the axillary lymph nodes (simple mastectomy plus axillary dissection)


Positive lymph nodes; advanced disease.


Radical mastectomy*


Removal of entire breast, pectoral muscles, axillary nodes


Rarely done today—may be performed for advanced disease.


* Mastectomy may be followed by immediate or delayed reconstruction.

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Jul 20, 2016 | Posted by in NURSING | Comments Off on Breast Conditions

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