Atovaquone(a toe’ va kwon)
Mepron
PREGNANCY CATEGORY C
Drug class
Antiprotozoal
Therapeutic Actions
Directly inhibits enzymes required for nucleic acid and ATP synthesis in protozoa; effective against Pneumocystis carinii, now called Pneumocystis jiroveci.
Indications
Prevention and acute oral treatment of mild to moderate P. jiroveci pneumonia in patients who are intolerant to trimethoprim-sulfamethoxazole
Contraindications and Cautions
Contraindicated with development or history of potentially life-threatening allergic reactions to any of the components of the drug.
Use cautiously with severe P. jiroveci infections, the elderly, lactation, hepatic impairment.
Available Forms
Suspension—750 mg/5 mL
Dosages
Adults and patients 13–16 yr
Prevention of P. jiroveci pneumonia: 1,500 mg PO daily with a meal.
Treatment of P. jiroveci pneumonia: 750 mg PO bid with food for 21 days.
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