Armodafinil(are moe daff’ ih nill)
Nuvigil
PREGNANCY CATEGORY C
CONTROLLED SUBSTANCE C-IV
Drug Classes
CNS stimulant
Narcolepsy drug
Therapeutic Actions
A CNS stimulant that helps to improve vigilance and decrease excessive daytime sleepiness associated with narcolepsy and other sleep disorders. May act through dopaminergic mechanisms; exact mechanism of action is not known. Not associated with the cardiac and other systemic stimulatory effects of amphetamines.
Indications
To improve wakefulness in patients with excessive sleepiness associated with obstructive sleep apnea/hypopnea syndrome, narcolepsy, and shift work sleep disorder
Contraindications and Cautions
Contraindicated with known hypersensitivity to any component of the drug or to modafinil.
Use cautiously with a history of psychosis, depression, mania; pregnancy, lactation; history of drug abuse or dependence; hepatic impairment, LV hypertrophy, mitral valve prolapse, history of severe rash, Tourette syndrome.
Available Forms
Tablets—50, 150, 250 mg
Dosages
Adults
Obstructive sleep apnea/hypopnea syndrome, narcolepsy: 150–250 mg/day PO as a single dose in the morning.
Shift work sleep disorder: 150 mg/day PO taken 1 hr before start of work shift.
Patients with severe hepatic impairment, elderly patients
Consider use of a lower dose.
Pharmacokinetics
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