9 Antifungals
The student should be aware of:
common fungal infections in pregnancy and postnatal care
the physiology and pathophysiology that allow these infections to flourish
BP
Nystatin
Proprietary
Nystan® (E.R. Squibb and Sons Ltd)
Nystaform® cream (Typharm Ltd)
Nystaform® cream (Typharm Ltd)
Group
Antifungal
Uses/indications
Candidiasis in the mouth, oesophagus or intestinal tract
Type of drug
POM
Presentation
Oral suspension (yellow), cream (light yellow)
Dosage
Adult: oral – 500 000 units q.d.s. for 7 days, i.e. 5 mL suspension (contains sugar); cream –100 000 units/g 2–3 times per day to affected skin
Paediatric: oral – 100 000 units q.d.s. for 7 days, i.e. 1 mL suspension (contains sugar)
Paediatric: oral – 100 000 units q.d.s. for 7 days, i.e. 1 mL suspension (contains sugar)
Route of admin
Oral
Contraindications
Hypersensitivity to constituents
Side effects
Nausea, vomiting, hypersensitivity
Interactions
No data available
Pharmacodynamic properties
Antifungal that is not absorbed by the gastrointestinal tract, skin or vagina, and that inhibits growth of microbes, mostly yeasts and yeast-like fungi, e.g. Candida albicans
Fetal risk
No reports of complications after administration in pregnancy
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