1 Anaesthesia
The student should be aware of:
the difference between analgesia and anaesthesia
the difference between local, regional and general anaesthesia
the physiology and pathophysiology of the perception of pain
the physiological principles underpinning epidural anaesthesia
problems that occur with obstetrical anaesthesia, i.e. the effects of progesterone on the mother, the presence of two patients rather than one, the pressure of the gravid uterus
updated resuscitation techniques
how to apply cricoid pressure if requested to in an emergency.
BP
Nitrous oxide
Proprietary
Entonox™ (BOC Healthcare)
Group
Anaesthetic, inhalational
Uses/indications
Analgesia during labour
Type of drug
POM, midwives’ exemptions or PGD
Presentation
Colourless gas with slightly sweet odour in cylinders – blue with blue and white quarters at the valve end and labelled Entonox
Cylinders should be: stored under cover; not stored near stocks of combustible materials
F size cylinders and larger should be stored vertically. D size cylinders and smaller may be stored horizontally
ensure cylinders are maintained at a temperature above 10°C for at least 24 h before use to ensure the gases are mixed correctly. Care needed when handling and using gas-filled cylinders, including transportation – cylinders should be separate from the driver area, securely held, and emergency procedures known to the driver. Use of a hazard warning label is essential
Cylinders should be: stored under cover; not stored near stocks of combustible materials
F size cylinders and larger should be stored vertically. D size cylinders and smaller may be stored horizontally
ensure cylinders are maintained at a temperature above 10°C for at least 24 h before use to ensure the gases are mixed correctly. Care needed when handling and using gas-filled cylinders, including transportation – cylinders should be separate from the driver area, securely held, and emergency procedures known to the driver. Use of a hazard warning label is essential
Dosage
50% nitrous oxide : 50% oxygen, self-administered via mask or Entonox™ equipment
Route of admin
Inhalational
Contraindications
Pneumothorax, facial or jaw injuries, diving accidents, overt drunkenness
Side effects
Drowsiness, nausea, vomiting
Interactions
None specific, but BNF (2011) indicates that it may be appropriate to consider that nitrous oxide enhances the effect of other anaesthetics or analgesics, and is similar in action to a general anaesthetic. Relevant interactions to obstetrics are that:
Pharmacodynamic properties
Medical gas – colourless
Oxygen – odourless and present in the atmosphere at 21%; nitrous oxide – sweet smelling and potent analgesic from endorphin release when at 25% concentration, but weak anaesthetic
Oxygen – odourless and present in the atmosphere at 21%; nitrous oxide – sweet smelling and potent analgesic from endorphin release when at 25% concentration, but weak anaesthetic
Fetal risk
Can depress neonatal respiration (BNF 2011). It is also of note that it may increase the risk of spontaneous abortion and low birthweight in female workers where levels of exposure are raised, i.e. operating theatres, labour wards
Breastfeeding
No data available on controlled studies during breastfeeding
BP
Lidocaine hydrochloride
Proprietary
Lidocaine hydrochloride 1% and 2% (Goldshield Group Ltd)
Group
Local anaesthetic
Uses/indications
Perineal infiltration – prior to episiotomy or suturing, or for nerve blocks
Emergency use, e.g. cardiac arrest – see Chapter 25 for indications, usage, and dosage
Emergency use, e.g. cardiac arrest – see Chapter 25 for indications, usage, and dosage
Type of drug
POM, midwives’ exemptions or PGD
Presentation
Glass or polypropylene ampoules 2, 5, 10 or 20 mL, with strength, 1% or 2%, indicated on the ampoule
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