Amoxicillin Trihydrate(a mox i sill’ in try high’ drayt)
Amoxil, Apo-Amoxi (CAN), DisperMox, Gen-Amoxicillin (CAN), MoxatagDNC, Novamoxin (CAN), Nu-Amoxi (CAN), Trimox
PREGNANCY CATEGORY B
Drug class
Antibiotic (penicillin–ampicillin type)
Therapeutic Actions
Bactericidal: Inhibits synthesis of cell wall of sensitive organisms, causing cell death.
Indications
Treatment of tonsillitis and pharyngitis caused by Streptococcus pyogenes (ER tablet)
Infections due to susceptible strains of Haemophilus influenzae, Escherichia coli, Proteus mirabilis, Neisseria gonorrhoeae, Streptococcus pneumoniae, Enterococcus faecalis, streptococci, non–penicillinase-producing staphylococci
Helicobacter pylori infection in combination with other agents
Postexposure prophylaxis against Bacillus anthracis
Unlabeled uses: Chlamydia trachomatis in pregnancy, mild to moderate otitis media in children, Lyme disease
Contraindications and Cautions
Contraindicated with allergies to penicillins, cephalosporins, or other allergens.
Use cautiously with renal disorders, lactation.
Available Forms
Chewable tablets—125, 200, 250 mg; tablets—500, 875 mg; capsules—250, 500 mg; powder for oral suspension—125 mg/5 mL, 200 mg/5 mL, 250 mg/5 mL, 400 mg/5 mL; tablets for oral suspension—200, 400 mg; ER tabletsDNC—775 mg
Available in oral preparations only.
Dosages
Adults and pediatric patients weighing more than 40 kg
URIs, GU infections, skin and soft-tissue infections: Mild to moderate—250 mg PO every 8 hr—500 mg PO every 12 hr; severe infection—500 mg every 8 hr or 875 mg every 12 hr.
Postexposure anthrax prophylaxis: 500 mg PO tid to complete a 60-day course after 14–21 days of a fluoroquinolone or doxycycline.
Lower respiratory infections: 500 mg PO every 8 hr or 875 mg PO bid.
Uncomplicated gonococcal infections: 3 g amoxicillin PO as a single dose.
C. trachomatis in pregnancy: 500 mg PO tid for 7 days or 875 mg PO bid.
Tonsillitis or pharyngitis: 775 mg/day PO for 10 days with food (ER tablet).
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