Amikacin Sulfate



Amikacin Sulfate





(am i kay’ sin)

Amikin

PREGNANCY CATEGORY D


Drug class

Aminoglycoside


Therapeutic Actions

Bactericidal: Inhibits protein synthesis in susceptible strains of gram-negative bacteria, and the functional integrity of bacterial cell membrane appears to be disrupted, causing cell death.


Indications



  • Short-term treatment of serious infections caused by susceptible strains of Pseudomonas species, Escherichia coli, indole-positive and indole-negative Proteus species, Providencia species, Klebsiella, Enterobacter, and Serratia species, Acinetobacter species


  • Suspected gram-negative infections before results of susceptibility studies are known (effective in infections caused by gentamicin- or tobramycin-resistant strains of gram-negative organisms)


  • Initial treatment of staphylococcal infections when penicillin is contraindicated or infection may be caused by mixed organisms


  • Treatment of serious infections such as bacterial septicemia (including neonatal sepsis); infections of the respiratory tract, bones, joints, CNS, skin and soft tissues; intra-abdominal infections; postoperative infections; recurrent and complicated UTIs


  • Unlabeled uses: Aerosolized for the treatment of pneumonia or cystic fibrosis; second-line therapy for drug-resistant tuberculosis



Available Forms

Injection—50 mg/mL, 250 mg/mL


Dosages

Adults and pediatric patients

15 mg/kg/day IM or IV divided into two to three equal doses at equal intervals, not to exceed 1.5 g/day. Usual course of treatment is 7–10 days. Uncomplicated infections should respond in 24–48 hr. If no clinical response is seen in 3–5 days, reevaluate therapy.



  • UTIs: 250 mg bid IM or IV; treatment is usually required for 7–10 days. If treatment is required for longer, carefully monitor serum levels and renal and neurologic function.

Neonatal patients

Loading dose of 10 mg/kg IM or IV; then 7.5 mg/kg every 12 hr.

Geriatric patients or patients with renal failure

Give normal doses at prolonged intervals or reduced dosage at fixed intervals based on CrCl or serum creatinine levels: CrCl 30–80 mL/min, give 4–12 mg/kg every 24 hr; CrCl 10–30 mL/min, give 4–7.5 mg/kg every 48 hr; CrCl less than 10 mL/min, give 3 mg/kg every 12 hr.

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Jul 20, 2016 | Posted by in NURSING | Comments Off on Amikacin Sulfate
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