Almotriptan Malate(al moh trip’ tan mah’ layt)
Axert
PREGNANCY CATEGORY C
Therapeutic Actions
Binds to serotonin receptors to cause vascular constrictive effects on cranial blood vessels, causing the relief of migraine in selective patients.
Indications
Treatment of acute migraines with or without aura
Contraindications and Cautions
Contraindicated with allergy to almotriptan, active coronary artery disease, Prinzmetal’s angina, peripheral or cerebrovascular syndromes, uncontrolled hypertension, use of an ergot compound or other triptan within 24 hours, pregnancy.
Use cautiously with hepatic or renal impairment, risk factors for CAD, lactation.
Available Forms
Tablets—6.25, 12.5 mg
Dosages
Adults
6.25–12.5 mg PO as a single dose at first sign of migraine; if headache returns, may be repeated after 2 hr; do not use more than 2 doses/24 hr. Maximum daily dose, 25 mg.
Pediatric patients
12–17 yr: 6.25–12.5 mg PO; may be repeated after 2 hr. Maximum daily dosage, 25 mg.
Safety and efficacy not established for patients younger than 12 yr.
Patients with hepatic or renal impairment
Starting dose—6.25 mg; do not exceed 12.5 mg/24 hr.
Geriatric patients
Reduced dosage may be needed; use with caution and monitor patient closely.
