Aliskiren(ah liss kye’ ren)
Tekturna
PREGNANCY CATEGORY C (FIRST TRIMESTER)
PREGNANCY CATEGORY D (SECOND AND THIRD TRIMESTERS)
Drug Classes
Antihypertensive
Renin inhibitor
Therapeutic Actions
Directly inhibits renin, which decreases plasma renin activity and inhibits conversion of angiotensinogen to angiotensin I. Inhibition of the renin-angiotensin-aldosterone system leads to decreased blood pressure, decreased aldosterone release, and decreased sodium resorption.
Indications
Treatment of hypertension, alone or with other antihypertensives
Contraindications and Cautions
Contraindicated with known hypersensitivity to any component of the drug, second or third trimester of pregnancy, lactation.
Use cautiously with history of impaired renal function, hyperkalemia.
Available Forms
Tablets—150, 300 mg
Dosages
Adults
150 mg/day PO. May be increased to 300 mg/day PO if needed to control BP.
Pediatric patients
Safety and efficacy not established.
Patients with severe renal impairment
No dosage adjustment needed with mild to moderate renal dysfunction; caution should be used with severe dysfunction because clinical experience is limited.
Pharmacokinetics
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