Chapter 10 Adverse drug reactions and drug interactions
INTRODUCTION
A tragic event occurred in the early 1960s that involved a hypnotic called thalidomide. This drug proved to be teratogenic, and many babies with congenital limb defects were born to mothers who had taken this preparation in early pregnancy. This major disaster led to the establishment of regulatory agencies that enforce rigorous testing and evaluation of drugs prior to the granting of a product licence and subsequent marketing. In addition to these processes, detection and recording of ADRs that occur when the drug is in use are of vital importance. A well-established reporting system enables ADRs to be reported to the Committee on Safety of Medicines. Both prescribed and non-prescribed medicines are included in this system. Yellow reporting forms for ADRs are included in the British National Formulary (BNF).
CLASSIFICATION
The simplest classification of ADRs is into types A and B.
DRUG-INDUCED GASTROINTESTINAL DISORDERS
Non-steroidal anti-inflammatory drugs including aspirin are very widely used but have a potential to damage the gastrointestinal tract. NSAIDs are administered to reduce pain and inflammation, particularly in arthritis. This is achieved by inhibition of synthesis of certain prostaglandins. However, they also inhibit prostaglandins, which are protective to tissues, resulting in irritant effects on the gastric epithelium.
Table 10.1 provides details of several of the more commonly experienced gastrointestinal adverse effects (dry mouth, taste disturbance, oesophageal reflux, nausea and vomiting, diarrhoea and constipation) and examples of drugs causing these.
Adverse drug reaction | Examples of drugs |
---|---|
Dry mouth | Anticholinergics, antihistamines, central nervous system stimulants, ribavirin, tricyclic antidepressants, phenothiazines |
Metallic taste | Metformin, metronidazole, zopiclone |
Taste disturbance | Angiotensin-converting enzyme inhibitors, penicillamine, terbinafine |
Oesophageal reflux | Anticholinergics, calcium-channel blockers, opioids |
Nausea and vomiting | Cytotoxics, levodopa, opioids, quinolones, ribavirin |
Diarrhoea | Antibiotics, colchicine, gold compounds, misoprostol, proton pump inhibitors |
Constipation | Anticholinergics, antihistamines, diuretics, iron preparations, opioid analgesics, tricyclic antidepressants, verapamil |
DRUG-INDUCED MENTAL HEALTH DISORDERS
PSYCHIATRIC CONDITIONS
Patients suffering from acute confusional states have a short attention span, appear bewildered and have difficulty following commands. Delirium is characterised by disorientation and reduced attention, and the patient may be frightened, restless and hostile. Most drug-induced confusional states resolve on withdrawal of the drug. Antimuscarinics are recognised as causing delirium, disorientation, confusion and visual hallucinations. Table 10.2 lists drugs associated with drug-induced mental disorders.
Condition | Examples of drugs associated with the condition |
---|---|
Depression | Ciprofloxacin, beta-blockers, calcium-channel blockers, benzodiazepines, levodopa, carbamazepine, phenothiazines, rivastigmine, corticosteroids, disulfiram, levetiracetam, isotretinoin, mefloquine |
Psychosis | Quinolones, anticholinergics, antiepileptics, disulfiram, ganciclovir, levodopa, mefloquine, zolpidem |
Mania | Baclofen, bromocriptine, corticosteroids, levodopa |
Delirium | Anticholinergics, antiepileptics, antipsychotics, corticosteroids, disulfiram, lithium, opioids |
Confusion | Diazepam, carbamazepine, mexiletine, omeprazole, spironolactone |
DRUG-INDUCED SKIN DISORDERS
Drug-induced skin eruptions are likely to be the most frequent adverse reaction seen by a nurse, because approximately 30% of reported drug reactions involve the skin. Reactions are frequently seen after immunisations and can range from mild to more severe (Fig. 10.1).
URTICARIA
Urticaria is referred to as hives or nettle rash and is an acute or a chronic allergic reaction in which red weals develop. The weals itch intensely and may last for hours or days. Sometimes, urticaria affects areas other than the skin, causing swelling of the tongue, lips and eyelids. This serious variety is called angioedema and requires urgent medical attention. Only acute urticaria is likely to be drug-induced, occurring straight away or shortly after the administration of a drug to a sensitised patient, and it can be regarded as the cutaneous manifestation of anaphylaxis. Urticaria may arise following treatment with, for example, penicillins, vaccines, indometacin, imipramine, aspirin, dextrans and X-ray contrast media.