34 The patient with anaphylactic or neurogenic shock will present with intense peripheral vasodilatation. Both are a distributive form of shock. These disorders, whilst having this common pathophysiological characteristic, vary greatly in their aetiology, clinical presentation and the therapeutic interventions required to successfully manage them. An antigen is a substance that provokes immune response and reactivity in the body and in health, the immune system effectively protects against the foreign and infectious antigens that it encounters. Sometimes, however, it reacts inappropriately to them with either a deficient or an exaggerated ‘hypersensitive’ response. There are four different types of hypersensitivity, three of which are mediated by antibodies and one by T lymphocytes. An allergen
Acute circulatory failure 2: distributive (anaphylaxis and neurogenic)
The immune response, allergy and anaphylaxis
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