Acebutolol Hydrochloride(a se byoo’ toe lole)
Apo-Acebutolol (CAN), Gen-Acebutolol (CAN), Rhotral (CAN), Sectral
PREGNANCY CATEGORY B
Drug Classes
Antiarrhythmic
Antihypertensive
Beta1-selective adrenergic blocker
Therapeutic Actions
Blocks beta-adrenergic receptors of the sympathetic nervous system in the heart and juxtaglomerular apparatus (kidney); decreases excitability of the heart, cardiac output and oxygen consumption, and release of renin from the kidneys; and lowers BP.
Indications
Hypertension, alone or with other antihypertensive drugs, especially diuretics
Management of ventricular premature beats
Unlabeled uses: Ventricular tachycardia, thyrotoxicosis, essential tremor
Contraindications and Cautions
Contraindicated with bradycardia (HR lower than 45 beats per min), second- or third-degree heart block (PR interval greater than 0.24 sec), cardiogenic shock, heart failure, asthma, lactation.
Use cautiously with diabetes or thyrotoxicosis, hepatic impairment, renal failure, pregnancy, bronchospastic disease, peripheral vascular disease, COPD, anesthesia, major surgery.
Available Forms
Capsules—200, 400 mg
Dosages
Adults
Hypertension: Initially 400 mg/day in one or two doses PO; usual maintenance dosage range is 200 mg/day, up to 1,200 mg/day given in two divided doses.
Ventricular arrhythmias: 200 mg bid PO; increase dosage gradually until optimum response is achieved (usually at 600–1,200 mg/day); discontinue gradually over 2 wk.
Pediatric patients
Safety and efficacy not established.
Geriatric patients
Because bioavailability doubles, lower doses may be required; maintain at 800 mg/day or less.
Patients with impaired renal or hepatic function
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