A. Group of symptoms resulting from hypercortisolism due to numerous causes

B. Excess adrenocorticotropic hormone (ACTH) secretion by the pituitary accounts for 90% of Cushing’s syndrome; it is therefore referred to as Cushing’s disease.

A. Excess ACTH production from the pituitary; approximately 70% of cases of Cushing’s syndrome are caused by benign pituitary adenomas

B. Adrenal neoplasms account for approximately 10% to 15% of cases; women are affected more often than men at a 3 to 5:1 ratio.

C. Nonpituitary neoplasms such as small cell lung cancer account for approximately 15% of cases.

D. Excessive glucocorticoid administration, including prolonged use