Zafirlukast(zah fur’ luh kast)
Accolate
PREGNANCY CATEGORY B
Drug Classes
Antiasthmatic
Leukotriene receptor antagonist
Therapeutic Actions
Selectively and competitively blocks receptor for leukotriene D4 and E4, components of SRS-A, thus blocking airway edema, smooth muscle constriction, and cellular activity associated with inflammatory process that contribute to signs and symptoms of asthma.
Indications
Prophylaxis and long-term treatment of bronchial asthma in adults and children 5 yr and older
Unlabeled use: Chronic urticaria
Contraindications and Cautions
Contraindicated with hypersensitivity to zafirlukast or any of its components, acute asthma attacks, status asthmaticus, hepatic impairment including hepatic cirrhosis.
Use cautiously in patients who previously required corticosteroid therapy to control asthma; with renal impairment; as oral steroid use is decreased; pregnancy; lactation.
Available Forms
Tablets—10, 20 mg
Dosages
Adults and patients 12 yr and older
20 mg PO bid on an empty stomach 1 hr before or 2 hr after eating.
Pediatric patients 5–11 yr
10 mg PO bid on an empty stomach, 1 hr before or 2 hr after eating.
Pharmacokinetics
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