Venlafaxine Hydrochloride(vin lah facks’ in)
Effexor XRDNC
PREGNANCY CATEGORY C
Drug Classes
Antidepressant
Serotonin/norephinephrine reuptake inhibitor
Therapeutic Actions
Potentiates the neurotransmitter activity in the CNS; inhibits serotonin, norepinephrine, and dopamine reuptake leading to prolonged stimulation at neuroreceptors.
Indications
Treatment of major depressive disorder
Treatment of generalized anxiety disorder (ER capsules only)
Treatment of social anxiety disorder (ER only)
Treatment of panic disorder, with or without agoraphobia (ER capsules only)
Unlabeled uses: PMDD, hot flushes, autism, pain, binge-eating disorder, diabetic neuropathy, migraine prevention
Available Forms
Tablets—25, 37.5, 50, 75, 100 mg; ER capsulesDNC—37.5, 75, 150 mg; ER tabletsDNC—37.5, 75, 150, 225 mg
Dosages
Adults
Depression: Starting dose, 75 mg/day PO in two to three divided doses taken with food. May be increased at intervals of no less than 4 days up to 225 mg/day PO to achieve desired effect; maximum dose 375 mg/day PO in three divided doses. ER forms: 37.5 mg/day PO may; increase to 75 mg/day PO in 4–7 days. Maximum dose, 225 mg/day.
Transfer to or from MAOI: At least 14 days should elapse from the discontinuation of the MAOI and the starting of venlafaxine; allow at least 7 days to elapse from the stopping of venlafaxine to the starting of an MAOI.
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