Trimethoprim (TMP)(trye meth’ oh prim)
Primsol
PREGNANCY CATEGORY C
Drug class
Antibacterial
Therapeutic Actions
Inhibits folic acid reduction to tetrahydrofolate in susceptible bacteria; the bacterial enzyme involved in this reaction is more readily inhibited than the mammalian enzyme.
Indications
Uncomplicated UTIs caused by susceptible strains of Eschirichia coli, Proteus mirabilis, Klebsiella pneumoniae, Enterobacter species, and coagulase-negative Staphylococcus species, including S. saprophyticus
Treatment of acute otitis media due to susceptible strains of Streptococcus pneumoniae and Haemophilus influenzae in children
Unlabeled uses: With dapsone for treatment of initial episodes of Pneumocystis jiroveci (carinii) pneumonia in patients who cannot tolerate co-trimoxazole; treatment and prevention of traveler’s diarrhea
Contraindications and Cautions
Contraindicated with allergy to trimethoprim, pregnancy (teratogenic in preclinical studies), megaloblastic anemia due to folate deficiency.
Use cautiously with hepatic or renal impairment, lactation.
Available Forms
Tablets—100, mg; solution—50 mg/5 mL
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