Triamterene(trye am’ ter een)
Dyrenium
PREGNANCY CATEGORY C
Drug class
Potassium-sparing diuretic
Therapeutic Actions
Inhibits sodium reabsorption in the renal distal tubule, causing loss of sodium and water and retention of potassium.
Indications
Edema associated with HF, nephrotic syndrome, hepatic cirrhosis; steroid-induced edema, edema from secondary hyperaldosteronism (alone or with other diuretics for added diuretic or potassium-sparing effects), hypertension
Unlabeled use: Pediatric hypertension
Contraindications and Cautions
Contraindicated with allergy to triamterene, hyperkalemia, renal disease (except nephrosis), liver disease, lactation.
Use cautiously with diabetes mellitus, hyperuricemia, pregnancy.
Available Forms
Capsules—50, 100 mg
Dosages
Adults
Edema: 100 mg bid PO if used alone after meals. Reduce dosage if added to other diuretic or antihypertensive therapy. Maintenance dosage should be individualized, may be as low as 100 mg every other day. Do not exceed 300 mg/day.
Hypertension: Start with 25 mg PO once daily; usual dose 50–100 mg/day.
Pediatric patients
Safety and efficacy not established.
Pharmacokinetics
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