Tizanidine(tis an’ i deen)
Apo-Tizanidine (CAN), Zanaflex
PREGNANCY CATEGORY C
Drug Classes
Alpha2-adrenergic agonist (centrally acting)
Antispasmodic
Sympatholytic (centrally acting)
Therapeutic Actions
Centrally acting alpha2-agonist; antispasmodic effect thought to be a result of indirect depression of polysynaptic reflexes by blocking the excitatory actions of spinal motor neurons.
Indications
Acute and intermittent management of increased muscle tone associated with spasticity
Contraindications and Cautions
Contraindicated with hypersensitivity to tizanidine, concomitant use of fluvoxamine, ciprofloxacin.
Use cautiously with hepatic or renal impairment, hypotension, pregnancy, lactation.
Available Forms
Tablets—2, 4 mg; capsules—2, 4, 6 mg
Dosages
Adults
4 mg/day PO, increased in 2- to 4-mg increments as needed over 2–4 wk. Usual maintenance dose is 8 mg PO every 6–8 hr; maximum dose, 36 mg/day in divided doses.
Pediatric patients
Safety and efficacy not established.
Patients with renal or hepatic impairment
Use lower doses. Monitor response with renal impairment; use extreme caution with hepatic impairment.
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