Tiotropium Bromide(tye oh troh’ pee um)
Spiriva
PREGNANCY CATEGORY C
Drug Classes
Anticholinergic
Antimuscarinic
Bronchodilator
Therapeutic Actions
Competitively antagonistic at muscarinic receptor sites; causes smooth muscle relaxation, leading to bronchodilation.
Indications
Long-term once-daily maintenance treatment of bronchospasm associated with COPD, including chronic bronchitis and emphysema
Contraindications and Cautions
Contraindicated with allergy to atropine or its derivatives, ipratropium or any component of the product.
Use cautiously with narrow-angle glaucoma, prostatic hyperplasia, bladder neck obstruction, moderate to severe renal impairment (CrCl of 50 mL/min or less), pregnancy, lactation.
Available Forms
Powder for inhalation—18 mcg supplied with Handihaler inhalation device
Dosages
Adults
Two inhalations of the contents of one capsule per day using the Handihaler inhalation device.
Pediatric patients
Safety and efficacy not established.
Pharmacokinetics
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