Contraindicated with coma or severe CNS depression, blood dyscrasia, circulatory collapse, subcortical brain damage, Parkinson disease, liver damage, cerebral arteriosclerosis, coronary disease, severe hypotension or hypertension, pregnancy, lactation.

Use cautiously with respiratory disorders (“silent pneumonia”); glaucoma, prostatic hypertrophy; epilepsy or history of epilepsy (drug lowers seizure threshold); breast cancer; thyrotoxicosis (severe neurotoxicity); peptic ulcer, decreased renal function; myelography within previous 24 hr or scheduled within 48 hr; exposure to heat or phosphorous insecticides; children younger than 12 yr, especially those with chickenpox, CNS infections (children are especially susceptible to dystonias that may confound the diagnosis of Reye syndrome).