Tetracycline Hydrochloride(tet ra sye’ kleen)
Apo-Tetra (CAN), Nu-Tetra (CAN)
PREGNANCY CATEGORY D
Drug Classes
Antibiotic
Tetracycline
Therapeutic Actions
Bacteriostatic: Inhibits protein synthesis of susceptible bacteria, preventing cell replication.
Indications
Systemic administration
Infections caused by rickettsiae; Mycoplasma pneumoniae; agents of psittacosis, ornithosis, lymphogranuloma venereum and granuloma inguinale; Borrelia recurrentis, Haemophilus ducreyi, Yersinia pestis, Francisella tularensis, Bartonella bacilliformis, Bacteroides, Vibrio cholerae, Campylobacter fetus, Brucella, Escherichia coli, Enterobacter aerogenes, Shigella, Acinetobacter, Haemophilus influenzae, Klebsiella, trachoma
When penicillin is contraindicated, infections caused by Neisseria gonorrhoeae, Treponema pallidum, Treponema pertenue, Listeria monocytogenes, Clostridium, Bacillus anthracis, Fusobacterium fusiforme, Actinomyces
Adjunct to amebicides in acute intestinal amebiasis
Uncomplicated urethral, endocervical, or rectal infections in adults caused by Chlamydia trachomatis
Adjunctive therapy for severe acne
Contraindications and Cautions
Systemic administration and dermatologic solution
Contraindicated with allergy to any of the tetracyclines, pregnancy (toxic to the fetus), lactation, children younger than (causes damage to the teeth of infant).
Use cautiously with hepatic or renal impairment.
Available Forms
Capsules—250, 500 mg
Dosages
Adults
1–2 g/day PO in two to four equal doses. Up to 500 mg PO qid.
Brucellosis: 500 mg PO four times daily for 3 wk with 1 g streptomycin bid IM the first wk and daily the second wk.
Syphilis: 30–40 g PO in divided doses over 10–15 days (Sumycin); 500 mg PO four times daily for 15–30 days (all others).
Uncomplicated gonorrhea: 500 mg every 6 hr PO for 7 days.
Stay updated, free articles. Join our Telegram channel
Full access? Get Clinical Tree
