Terbinafine Hydrochloride(ter bin’ ah feen)
Apo-Terbinafine (CAN), CO Terbinafine (CAN), Gen Terbinafine (CAN), Lamisil, Lamisil AT, Lamisil Oral Granules, PMS-Terbinafine (CAN), Terbinex
PREGNANCY CATEGORY B
Drug Classes
Allylamine
Antifungal
Therapeutic Actions
A synthetic allylamine that is thought to block squalene oxidase, thus preventing the biosynthesis of ergosterol, an essential component of fungal cell walls.
Indications
Treatment of tinea capitis in patients 4 yr and older (oral granules)
Treatment of onychomycosis of the toenail or fingernail caused by dermatophytes
Topical treatment of tinea versicolor, tinea pedis, tinea cruris, tinea corporis
Contraindications and Cautions
Contraindicated with allergy to any component of the product, hepatic failure, lactation.
Use cautiously with hepatic impairment, renal impairment, immunodeficiency, pregnancy.
Available Forms
Tablets—250 mg; oral granules—125, 187.5 mg; cream, gel, spray—1%
Dosages
Adults
Fingernail onychomycosis: 250 mg/day PO for 6 wk.
Toenail onychomycosis: 250 mg/day PO for 12 wk.
Tinea capitis: 250 mg/day PO for 6 wk.
Pediatric patients
Tinea capitis
Weight less than 25 kg: 125 mg/day PO for 6 wk.
25–35 kg: 187.5 mg/day PO for 6 wk.
Weight more than 35 kg: 250 mg/day PO for 6 wk.
Stay updated, free articles. Join our Telegram channel
Full access? Get Clinical Tree
